| http://purl.uniprot.org/citations/22246992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22246992 | http://www.w3.org/2000/01/rdf-schema#comment | "Endoplasmic reticulum (ER) stress has been shown to be associated with the pathogenesis of neurodegenerative disorders including Parkinson's disease (PD). HtrA2/Omi, from its participation in protein quality control, is involved in ER stress. However, little is known about the relationship between HtrA2/Omi and ER stress in PD. Here, we explored the association of HtrA2/Omi and ER stress in a cell model of PD and found that the expression level of HtrA2/Omi decreased with ER stress induction in 6-OHDA-treated SH-SY5Y cells. Furthermore, silencing endogenous expression of HtrA2/Omi with siRNA resulted in aggregated ER stress and cell death. Taken together, our results show that HtrA2/Omi may exert a protective function in 6-OHDA-induced cell death by regulating ER stress-related proteins. This research offers some clues as why mutations in HtrA2/Omi lead to higher susceptibility in some PD patients."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12031-011-9694-0"xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/author | "Sun C."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/author | "Wei L."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/author | "Xu P."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/author | "Luo F."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/name | "J Mol Neurosci"xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/pages | "120-127"xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/title | "HtrA2/Omi is involved in 6-OHDA-induced endoplasmic reticulum stress in SH-SY5Y cells."xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/22246992 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22246992 |
| http://purl.uniprot.org/citations/22246992 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22246992 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG44-mappedCitation-22246992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246992 |
| http://purl.uniprot.org/uniprot/#_A0A384MDW9-mappedCitation-22246992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246992 |
| http://purl.uniprot.org/uniprot/#_A0A8Q3SIX7-mappedCitation-22246992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246992 |
| http://purl.uniprot.org/uniprot/#_A8K7G2-mappedCitation-22246992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246992 |
| http://purl.uniprot.org/uniprot/#_B2BKJ3-mappedCitation-22246992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246992 |
| http://purl.uniprot.org/uniprot/#_O43464-mappedCitation-22246992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246992 |