| http://purl.uniprot.org/citations/22248288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22248288 | http://www.w3.org/2000/01/rdf-schema#comment | "The endocrine fibroblast growth factor 21 (FGF21) requires both fibroblast growth factor receptor (FGFR) and β-Klotho for signaling. In this study, we sought to understand the inter-molecular physical interactions in the FGF21/FGFR/β-Klotho complex by deleting key regions in FGFR1c or FGF21. Deletion of the D1 and the D1-D2 linker (the D1/linker region) from FGFR1c led to β-Klotho-independent receptor activation by FGF21, suggesting that there may be a direct interaction between FGF21 and the D1/linker region-deficient FGFR1c. Consistent with this, the extracellular portion of FGFR1c lacking the D1/linker region blocked FGF21 action in a reporter assay, presumably by binding to and sequestering FGF21 from acting on cell surface receptor complex. In addition, the D1/linker region-deficient FGFR1c had enhanced interaction with β-Klotho. Further, we demonstrated that deletion of the D1/linker region enhanced the formation of the FGF21/β-Klotho/FGFR1c ternary complex in both Biacore and asymmetrical flow field flow fractionation studies. Finally, we found that the N-terminus of FGF21 is involved in the interaction with FGFR1c and FGF21/β-Klotho/FGFR1c ternary complex formation. Taken together, our data suggest that the D1/linker region regulates both the FGF21/FGFR1c and FGFR1c/β-Klotho interaction, and a direct interaction of FGF21 with FGFR1c may be an important step in receptor-mediated FGF21 signaling."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1747-0285.2012.01325.x"xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Stevens J."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Deng L."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Chen M.M."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Lindberg R."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Veniant M."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Hecht R."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Yie J."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/author | "Tam L.T."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/name | "Chem Biol Drug Des"xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/pages | "398-410"xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/title | "Understanding the physical interactions in the FGF21/FGFR/beta-Klotho complex: structural requirements and implications in FGF21 signaling."xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/22248288 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22248288 |
| http://purl.uniprot.org/citations/22248288 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22248288 |
| http://purl.uniprot.org/uniprot/#_A0A7U3L5M7-mappedCitation-22248288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22248288 |
| http://purl.uniprot.org/uniprot/#_B4DYH5-mappedCitation-22248288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22248288 |