| http://purl.uniprot.org/citations/22253232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22253232 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional regulation by p53 is thought to play a role in its ability to suppress tumorigenesis. However, there remain gaps in understanding about how p53 regulates transcription and how disrupting this function may promote cancer. Here we report a role in these processes for the kidney cancer-related gene KR-POK (ZBTB7C), a POZ domain and Krüppel-like zinc finger transcription factor that we found to physically interact with p53. Murine embryonic fibroblasts isolated from genetically deficient mice (Kr-pok(-/-) MEFs) exhibited a proliferative defect relative to wild-type mouse embryonic fibroblasts (MEF). The zinc finger domain of Kr-pok interacted directly with the DNA binding and oligomerization domains of p53. This interaction was essential for Kr-pok to bind the distal promoter region of the CDKN1A gene, an important p53 target gene encoding the cell-cycle regulator p21WAF1, and to inhibit p53-mediated transcriptional activation of CDKN1A. Kr-pok also interacted with the transcriptional corepressors NCoR and BCoR, acting to repress histone H3 and H4 deacetylation at the proximal promoter region of the CDKN1A gene. Importantly, Kr-pok(-/-) MEFs displayed an enhancement in CDKN1A transactivation by p53 during the DNA damage response, without any parallel changes in transcription of either the p53 or Kr-pok genes themselves. Furthermore, Kr-pok promoted cell proliferation in vitro and in vivo, and its expression was increased in more than 50% of the malignant human kidney cancer cases analyzed. Together, our findings define KR-POK as a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-11-2433"xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Kim K.S."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Choi K.Y."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Kim M.K."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Yoon J."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Hong S.Y."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Hur M.W."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Choi W.I."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Lee K.R."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Yun C.O."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Jeon B.N."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Koh D.I."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/author | "Nephew K.P."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/pages | "1137-1148"xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/title | "KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A."xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/22253232 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22253232 |
| http://purl.uniprot.org/citations/22253232 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22253232 |
| http://purl.uniprot.org/uniprot/#_E9Q9Y2-mappedCitation-22253232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22253232 |
| http://purl.uniprot.org/uniprot/#_E0CYX5-mappedCitation-22253232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22253232 |