| http://purl.uniprot.org/citations/22253830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22253830 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase 3 family, is activated by oxidative stress. The death-signaling pathway mediated by ASK1 is inhibited by DJ-1, which is linked to recessively inherited Parkinson's disease (PD). Considering that DJ-1 deficiency exacerbates the toxicity of the mitochondrial complex I inhibitor 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), we sought to investigate the direct role and mechanism of ASK1 in MPTP-induced dopamine neuron toxicity. In the present study, we found that MPTP administration to wild-type mice activates ASK1 in the midbrain. In ASK1 null mice, MPTP-induced motor impairment was less profound, and striatal dopamine content and nigral dopamine neuron counts were relatively preserved compared to wild-type littermates. Further, microglia and astrocyte activation seen in wild-type mice challenged with MPTP was markedly attenuated in ASK⁻/⁻ mice. These data suggest that ASK1 is a key player in MPTP-induced glial activation linking oxidative stress with neuroinflammation, two well recognized pathogenetic factors in PD. These findings demonstrate that ASK1 is an important effector of MPTP-induced toxicity and suggest that inhibiting this kinase is a plausible therapeutic strategy for protecting dopamine neurons in PD."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0029935"xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "Lee K.W."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "Ichijo H."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "Mouradian M.M."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "Jang W.H."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "Im J.Y."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "Junn E."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "German D.C."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "Sonsalla P.K."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "Chan T.W."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/author | "Grosso H."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/pages | "e29935"xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/title | "Apoptosis signal-regulating kinase 1 mediates MPTP toxicity and regulates glial activation."xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22253830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22253830 |
| http://purl.uniprot.org/citations/22253830 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22253830 |
| http://purl.uniprot.org/uniprot/#_Q14AY4-mappedCitation-22253830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22253830 |
| http://purl.uniprot.org/uniprot/#_O35099-mappedCitation-22253830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22253830 |
| http://purl.uniprot.org/uniprot/#_Q8CC79-mappedCitation-22253830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22253830 |
| http://purl.uniprot.org/uniprot/Q8CC79 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22253830 |