| http://purl.uniprot.org/citations/22253920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22253920 | http://www.w3.org/2000/01/rdf-schema#comment | "Backgroundp63 is a member of the p53 family that has been implicated in maintenance of epithelial stem cell compartments. Previous studies demonstrated that p63 is downregulated in muscle-invasive bladder cancers, but the relationship between p63 expression and survival is not clear.Methodology/principal findingsWe used real-time PCR to characterize p63 expression and several genes implicated in epithelial-to-mesenchymal transition (EMT) in human bladder cancer cell lines (n = 15) and primary tumors (n = 101). We correlated tumor marker expression with stage, disease-specific (DSS), and overall survival (OS). Expression of E-cadherin and p63 correlated directly with one another and inversely with expression of the mesenchymal markers Zeb-1, Zeb-2, and vimentin. Non-muscle-invasive (Ta and T1) bladder cancers uniformly expressed high levels of E-cadherin and p63 and low levels of the mesenchymal markers. Interestingly, a subset of muscle-invasive (T2-T4) tumors maintained high levels of E-cadherin and p63 expression. As expected, there was a strongly significant correlation between EMT marker expression and muscle invasion (p<0.0001). However, OS was shorter in patients with muscle-invasive tumors that retained p63 (p = 0.007).Conclusions/significanceOur data confirm that molecular markers of EMT are elevated in muscle-invasive bladder cancers, but interestingly, retention of the "epithelial" marker p63 in muscle-invasive tumors is associated with a worse outcome."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0030206"xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Adam L."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Tran M."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Wen S."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Choi W."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Lee I.L."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "McConkey D.J."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Dinney C."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Marquis L."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Shah J.B."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Siefker-Radtke A."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/author | "Svatek R."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/pages | "e30206"xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/title | "p63 expression defines a lethal subset of muscle-invasive bladder cancers."xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22253920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22253920 |
| http://purl.uniprot.org/citations/22253920 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22253920 |
| http://purl.uniprot.org/uniprot/#_A0A141PNN3-mappedCitation-22253920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22253920 |
| http://purl.uniprot.org/uniprot/#_A0A141PNN4-mappedCitation-22253920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22253920 |