| http://purl.uniprot.org/citations/22253936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22253936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22253936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22253936 | http://www.w3.org/2000/01/rdf-schema#comment | "Schistosomiasis is one of the most prevalent parasitic diseases, affecting millions of people in developing countries. Amongst the human-infective species, Schistosoma mansoni is also the most commonly used in the laboratory and here we present the systematic improvement of its draft genome. We used Sanger capillary and deep-coverage Illumina sequencing from clonal worms to upgrade the highly fragmented draft 380 Mb genome to one with only 885 scaffolds and more than 81% of the bases organised into chromosomes. We have also used transcriptome sequencing (RNA-seq) from four time points in the parasite's life cycle to refine gene predictions and profile their expression. More than 45% of predicted genes have been extensively modified and the total number has been reduced from 11,807 to 10,852. Using the new version of the genome, we identified trans-splicing events occurring in at least 11% of genes and identified clear cases where it is used to resolve polycistronic transcripts. We have produced a high-resolution map of temporal changes in expression for 9,535 genes, covering an unprecedented dynamic range for this organism. All of these data have been consolidated into a searchable format within the GeneDB (www.genedb.org) and SchistoDB (www.schistodb.net) databases. With further transcriptional profiling and genome sequencing increasingly accessible, the upgraded genome will form a fundamental dataset to underpin further advances in schistosome research."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pntd.0001455"xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pntd.0001455"xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pntd.0001455"xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Berriman M."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Berriman M."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Berriman M."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Holroyd N.E."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Holroyd N.E."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Holroyd N.E."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Lloyd C."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Lloyd C."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Lloyd C."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Quail M.A."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Quail M.A."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Quail M.A."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Aslett M.A."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Aslett M.A."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "Aslett M.A."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "McQuillan J."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "McQuillan J."xsd:string |
| http://purl.uniprot.org/citations/22253936 | http://purl.uniprot.org/core/author | "McQuillan J."xsd:string |