http://purl.uniprot.org/citations/22257687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22257687 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundMatrix metalloproteinase-8 (MMP-8) is involved in the breakdown of the extracellular matrix increasing the vulnerability of atherosclerotic lesions. We analysed the diagnostic value of serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in acute coronary syndrome (ACS) and their prognostic value in ACS recurrence.MethodsThe population comprised 343 patients with ACS [including 108 unstable angina pectoris and 235 acute myocardial infarctions (AMI)] and 326 healthy controls. Additionally, 157 (45.8%) patients were resampled during the recovery. The ACS patients were followed up for 6 years.ResultsMMP-8, TIMP-1, and their molar ratio distinguished the cases from the controls; C-statistic of the multivariate model (95% CI, p-value) including the MMP-8/TIMP-1 ratio regarding its discriminating ability for AMI was 0.922 (0.893-0.950, p<0.001). After the acute phase of ACS, median MMP-8 and TIMP-1 concentrations decreased (p<0.001) by 34.5 and 28.7%, respectively, but ended up on a different level than those found in the controls. In the follow-up, acute phase and recovery period TIMP-1 concentrations associated with cardiovascular death with hazard ratios 4.31 (2.00-9.26, p<0.001) and 4.69 (1.10-20.01, p=0.037), respectively.ConclusionsThe increase of serum MMP-8 and TIMP-1 concentrations may reflect plaque instability and tissue damage. TIMP-1 concentrations are associated with poor outcome in patients with ACS. The findings may have practical implications in both diagnostics and therapeutics."xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ijcard.2011.12.095"xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/author | "Puolakkainen M."xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/author | "Sorsa T."xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/author | "Pussinen P.J."xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/author | "Sarna S."xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/author | "Pesonen E."xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/author | "Ohlin H."xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/name | "Int J Cardiol"xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/pages | "362-368"xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/title | "The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence."xsd:string |
http://purl.uniprot.org/citations/22257687 | http://purl.uniprot.org/core/volume | "167"xsd:string |
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http://purl.uniprot.org/uniprot/#_P22894-mappedCitation-22257687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22257687 |
http://purl.uniprot.org/uniprot/#_P01033-mappedCitation-22257687 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22257687 |
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