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http://purl.uniprot.org/citations/22259066http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22259066http://www.w3.org/2000/01/rdf-schema#comment"

Context

Hashimoto's thyroiditis (HT) is a common autoimmune disease leading to thyroid destruction due to lymphocytic infiltration. Only rare data are available regarding the recognition of specific cellular antigens, e.g. of thyroperoxidase (TPO) and thyroglobulin (Tg).

Objective

The aim of this study was to quantify and characterize TPO- and Tg-epitope-specific CD8-positive T cells of HT patients.

Design

Six different human leukocyte antigen (HLA)-A2 restricted, TPO- or Tg-specific tetramers were synthesized and used for measuring CD8-positive T cells in HT patients and controls.

Results

The frequency of peripheral TPO- and Tg-specific CD8-positive T cells was significantly higher in HLA-A2-positive HT patients (2.8 ± 9.5%) compared with HLA-A2-negative HT patients (0.5 ± 0.7%), HLA-A2-positive nonautoimmune goiter patients (0.2 ± 0.4%), and HLA-A2-positive healthy controls (0.1 ± 0.2%). The frequency of Tg-specific T cells (3.0%) was very similar to those of TPO-specific CD8-positive T cells (2.9%). Subgroup analyses revealed a steady increase of the number of epitope-specific CD8-positive T cells from 0.6 ± 1.0% at initial diagnosis up to 9.4 ± 18.3% in patients with long-lasting disease. Analyses of the number of thyroid-infiltrating cells as well as the cytotoxic capacity revealed a similar picture for TPO- and Tg-specific T cells.

Conclusion

We here report for the first time that both antigens, TPO and Tg, are recognized by CD8-positive T cells and are involved in the thyroid destruction process leading to clinical disease manifestation."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.org/dc/terms/identifier"doi:10.1210/jc.2011-2178"xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/author"Schinner S."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/author"Thiel A."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/author"Scherbaum W.A."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/author"Willenberg H.S."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/author"Schott M."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/author"Ehlers M."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/author"Papewalis C."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/author"Bernecker C."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/author"Hautzel H."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/author"Porwol D."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/name"J Clin Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/pages"1347-1354"xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/title"Evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto's thyroiditis."xsd:string
http://purl.uniprot.org/citations/22259066http://purl.uniprot.org/core/volume"97"xsd:string
http://purl.uniprot.org/citations/22259066http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22259066
http://purl.uniprot.org/citations/22259066http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22259066
http://purl.uniprot.org/uniprot/#_A1L1A0-mappedCitation-22259066http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22259066
http://purl.uniprot.org/uniprot/#_A0A5P9KEK2-mappedCitation-22259066http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22259066
http://purl.uniprot.org/uniprot/#_A0A5P9KIV3-mappedCitation-22259066http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22259066
http://purl.uniprot.org/uniprot/#_A0A3G5AJ89-mappedCitation-22259066http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22259066
http://purl.uniprot.org/uniprot/#_A0A3Q9NB19-mappedCitation-22259066http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22259066
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