| http://purl.uniprot.org/citations/22260507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22260507 | http://www.w3.org/2000/01/rdf-schema#comment | "The Toll-like receptors (TLRs) 3, 7, 8 and 9 stimulate innate immune responses upon recognizing pathogen-derived nucleic acids. TLR3 is located on the cell surface and in cellular endosomes and recognizes double-stranded viral RNA or the synthetic mimic poly rI:rC. Recently, unformulated small interfering RNA (siRNA) has been reported as ligand for surface-expressed murine TLR3. Blockage of TLR3 is achieved by single-stranded DNA. We confirm and expand the observation that poly rI:rC-mediated TLR3 immune activation is blocked in a sequence-, length-, backbone- and CpG-dependent manner. However, human TLR3 is not activated by siRNA, which may be the result of differences in the amino acid composition of the TLR3 loop 1 of mice and humans. Although CD14 was previously described as a co-receptor for murine TLR3 and other nucleic acid-recognizing TLRs, human CD14 acts only as co-receptor to human TLR9, but not TLR3, TLR7 or TLR8. We show that CD14 up-regulates the TLR9 immune response of A, B and C-class oligodeoxynucleotides but down-regulates the phosphoro-diester version of B-class oligodeoxynucleotides."xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2567.2012.03559.x"xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/author | "Weber C."xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/author | "Muller C."xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/author | "Vollmer J."xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/author | "Forsbach A."xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/author | "Montino C."xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/author | "Podszuweit A."xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/pages | "64-77"xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/title | "Toll-like receptor (TLR) 3 immune modulation by unformulated small interfering RNA or DNA and the role of CD14 (in TLR-mediated effects)."xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/22260507 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22260507 |
| http://purl.uniprot.org/citations/22260507 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22260507 |
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