Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/22261574http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22261574http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The ω-3 polyunsaturated fatty acid therapy in inflammatory bowel disease is focused on the effects on fish oil-derived polyunsaturated fatty acids. We speculated that a vegetal oil rich in α-linolenic acid (ALA) might also inhibit colitis. Therefore, we evaluated whether dietary ALA would decrease the expression of adhesion molecules by inducing the protective enzyme heme oxygenase-1 (HO-1) in a rat colitis model.

Methods

Colitis was induced at day 0 by an intrarectal injection of 2-4-6-trinitrobenzen sulfonic acid (TNBS), whereas control rats received the vehicle. Rats were fed an ALA-rich formula 450 mg · kg⁻¹ · d⁻¹, whereas the other colitic group (TNBS) and the control group were fed an isocaloric corn oil formula for 14 d (from day -7 to day 7). The colonic expressions of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), vascular endothelial growth factor A receptor-2 (VEGFR2), and HO-1 were studied by immunohistochemistry.

Results

The ALA-rich diet significantly decreased the expression of ICAM-1, VCAM-1, and VEGFR-2 compared the TNBS group, but it did not affect the expression of HO-1.

Conclusion

A vegetal ALA-rich formula decreases the expression of ICAM-1, VCAM-1, and VEGFR-2 and independently of HO-1 in rats with TNBS-induced colitis. Further studies are required to evaluate its therapeutic potential in inflammatory bowel disease as an alternative to fish oil."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.org/dc/terms/identifier"doi:10.1016/j.nut.2011.10.008"xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/author"Hassan A."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/author"Aziz M."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/author"Ibrahim A."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/author"Dechelotte P."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/author"Coeffier M."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/author"Bounoure F."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/author"Collasse E."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/author"Marion-Letellier R."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/author"Mbodji K."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/author"Savoye G."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/name"Nutrition"xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/pages"799-802"xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/title"Dietary alpha-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis."xsd:string
http://purl.uniprot.org/citations/22261574http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/22261574http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22261574
http://purl.uniprot.org/citations/22261574http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22261574
http://purl.uniprot.org/uniprot/#_A0A0G2K090-mappedCitation-22261574http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22261574
http://purl.uniprot.org/uniprot/#_A0A0G2K127-mappedCitation-22261574http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22261574
http://purl.uniprot.org/uniprot/#_A0A8L2Q9Q0-mappedCitation-22261574http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22261574
http://purl.uniprot.org/uniprot/#_A0A8L2QF25-mappedCitation-22261574http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22261574
http://purl.uniprot.org/uniprot/#_A0A8L2UJE9-mappedCitation-22261574http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22261574
▶