| http://purl.uniprot.org/citations/22261707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22261707 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysplasia in Barrett esophagus has been recognized to be morphologically heterogenous, featuring adenomatous, foveolar, and hybrid phenotypes. Recent studies have suggested a tumor suppressor role for CDX-2 in the metaplasia-dysplasia-carcinoma sequence. The phenotypic stability and role of CDX-2 in the neoplastic progression of different types of dysplasias have not been evaluated. Thirty-eight endoscopic mucosal resections with dysplasia and/or intramucosal carcinoma (IMC) arising in Barrett esophagus were evaluated for the expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2. The background mucosa was also evaluated. The results were correlated with morphologic classification and clinicopathologic parameters. Of 38 endoscopic mucosal resections, 23 had IMC and dysplasia, 8 had IMC only, and 7 had dysplasia only. Among dysplastic lesions, 73% were foveolar, 17% were adenomatous, and 10% were hybrid. Twenty of 23 cases with dysplasia and adjacent IMC showed an identical immunophenotype of dysplasia and IMC comprising 16 gastric, 3 intestinal, and 1 mixed immunophenotype. Three cases showed discordance of dysplasia and IMC immunophenotype. These findings suggest that most Barrett-related IMC cases are either gastric or intestinal, with phenotypic stability during progression supporting separate gastric and intestinal pathways of carcinogenesis. CDX-2 showed gradual downregulation of expression during progression in adenomatous dysplasia but not in foveolar or hybrid dysplasia, supporting a tumor suppressor role, at least in the intestinal pathway. CDX-2 was also found to be expressed to a greater degree in intestinal metaplasia compared with nonintestinalized columnar metaplasia. Consistent with CDX-2 as a tumor suppressor, this suggests that nonintestinalized columnar metaplasia may be an unstable intermediate state at risk for neoplastic progression."xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.org/dc/terms/identifier | "doi:10.1097/pas.0b013e31823d08d6"xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/author | "Fujita H."xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/author | "Park Y."xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/author | "Srivastava A."xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/author | "Ooi E.M."xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/author | "Kumarasinghe M.P."xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/author | "Lauwers G.Y."xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/author | "Alfaro E.E."xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/author | "Khor T.S."xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/name | "Am J Surg Pathol"xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/pages | "331-342"xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/title | "Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett Esophagus?"xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/22261707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22261707 |
| http://purl.uniprot.org/citations/22261707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22261707 |
| http://purl.uniprot.org/uniprot/#_A0A076MKN9-mappedCitation-22261707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22261707 |
| http://purl.uniprot.org/uniprot/#_A0A0M3L9V7-mappedCitation-22261707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22261707 |
| http://purl.uniprot.org/uniprot/#_A0A3Q8TMU7-mappedCitation-22261707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22261707 |
| http://purl.uniprot.org/uniprot/#_H9XFB7-mappedCitation-22261707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22261707 |
| http://purl.uniprot.org/uniprot/#_H9XFB8-mappedCitation-22261707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22261707 |
| http://purl.uniprot.org/uniprot/#_H9XFB9-mappedCitation-22261707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22261707 |