| http://purl.uniprot.org/citations/22264729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22264729 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of G protein-coupled receptors (GPCRs) leads to the dissociation of heterotrimeric G-proteins into Gα and Gβγ subunits, which go on to regulate various effectors involved in a panoply of cellular responses. During chemotaxis, Gβγ subunits regulate actin assembly and migration, but the protein(s) linking Gβγ to the actin cytoskeleton remains unknown. Here, we identified a Gβγ effector, ElmoE in Dictyostelium, and demonstrated that it is required for GPCR-mediated chemotaxis. Remarkably, ElmoE associates with Gβγ and Dock-like proteins to activate the small GTPase Rac, in a GPCR-dependent manner, and also associates with Arp2/3 complex and F-actin. Thus, ElmoE serves as a link between chemoattractant GPCRs, G-proteins and the actin cytoskeleton. The pathway, consisting of GPCR, Gβγ, Elmo/Dock, Rac, and Arp2/3, spatially guides the growth of dendritic actin networks in pseudopods of eukaryotic cells during chemotaxis."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2011.11.007"xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/author | "Brzostowski J.A."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/author | "Parent C.A."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/author | "Jin T."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/author | "Veenstra T.D."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/author | "Mihaylov V."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/pages | "92-103"xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/title | "A Gbetagamma effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis."xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/22264729 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22264729 |
| http://purl.uniprot.org/citations/22264729 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22264729 |
| http://purl.uniprot.org/uniprot/Q54WH5#attribution-2AAE16064BE6C68BC055376BEBC84215 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22264729 |
| http://purl.uniprot.org/uniprot/Q54WH5#attribution-34E1B3BA9D8C8233782D11455D46183E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22264729 |
| http://purl.uniprot.org/uniprot/Q54WH5#attribution-D4CAA4F65D853814A29AFA78CC4E8DB5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22264729 |
| http://purl.uniprot.org/uniprot/P34148#attribution-2AAE16064BE6C68BC055376BEBC84215 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22264729 |
| http://purl.uniprot.org/uniprot/#_P13773-mappedCitation-22264729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22264729 |
| http://purl.uniprot.org/uniprot/#_O96623-mappedCitation-22264729 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22264729 |