| http://purl.uniprot.org/citations/22266216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22266216 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the role of endogenous neuropeptide Y (NPY) system in nicotine-mediated improvement of learning and memory in rat model of Alzheimer's disease (AD). Intracerebroventricular (icv) colchicine treatment induced AD-like condition in rats and showed increased escape latency (decreased learning), and amnesic condition in probe test in Morris water maze. In these rats, nicotine (0.5mg/kg, intraperitoneal), NPY (100 ng/rat, icv) or NPY Y1 receptor agonist [Leu(31), Pro(34)]-NPY (0.04 ng/rat, icv) decreased escape latency by 54.76%, 55.81% and 44.18%, respectively, on day 4 of the acquisition. On the other hand, selective NPY Y1 receptor antagonist, BIBP3226 (icv) produced opposite effect (44.18%). In the probe test conducted at 24h time point, nicotine, NPY or [Leu(31), Pro(34)]-NPY increased the time spent by 72.72%, 44.11% and 26.47%, respectively; while BIBP3226 caused reduction (8.82%). It seems that while NPY or [Leu(31), Pro(34)]-NPY potentiated, BIBP3226 attenuated the learning and memory enhancing effects of nicotine. Brains of colchicine treated rats showed significant reduction in NPY-immunoreactivity in the nucleus accumbens shell (cells 62.23% and fibers 50%), bed nucleus of stria terminalis (fibers 71.58%), central nucleus of amygdala (cells 74.33%), arcuate nucleus (cells 70.97% and fibers 69.65%) and dentate gyrus (cells 58.54%). However, in these rats nicotine treatment for 4 days restored NPY-immunoreactivity to the control level. We suggest that NPY, perhaps acting via NPY Y1 receptors, might interact with the endogenous cholinergic system and play a role in improving the learning and memory processes in the rats with AD-like condition."xsd:string |
| http://purl.uniprot.org/citations/22266216 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2012.01.004"xsd:string |
| http://purl.uniprot.org/citations/22266216 | http://purl.uniprot.org/core/author | "Subhedar N.K."xsd:string |
| http://purl.uniprot.org/citations/22266216 | http://purl.uniprot.org/core/author | "Kokare D.M."xsd:string |
| http://purl.uniprot.org/citations/22266216 | http://purl.uniprot.org/core/author | "Upadhya M.A."xsd:string |
| http://purl.uniprot.org/citations/22266216 | http://purl.uniprot.org/core/author | "Nakhate K.T."xsd:string |
| http://purl.uniprot.org/citations/22266216 | http://purl.uniprot.org/core/author | "Rangani R.J."xsd:string |
| http://purl.uniprot.org/citations/22266216 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22266216 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
| http://purl.uniprot.org/citations/22266216 | http://purl.uniprot.org/core/pages | "317-328"xsd:string |
| http://purl.uniprot.org/citations/22266216 | http://purl.uniprot.org/core/title | "Nicotine evoked improvement in learning and memory is mediated through NPY Y1 receptors in rat model of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/22266216 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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