| http://purl.uniprot.org/citations/22267734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22267734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22267734 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular levels of β-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer disease (AD) amyloid β-peptide (Aβ), are tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ATase1 and ATase2. Here we report that both acetyltransferases are expressed in neurons and glial cells, and are up-regulated in the brain of AD patients. We also report the identification of first and second generation compounds that inhibit ATase1/ATase2 and down-regulate the expression levels as well as activity of BACE1. The mechanism of action involves competitive and non-competitive inhibition as well as generation of unstable intermediates of the ATases that undergo degradation."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.310136"xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.310136"xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Ding Y."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Ding Y."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Pehar M."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Pehar M."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Puglielli L."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Puglielli L."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Ko M.H."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Ko M.H."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Peters N.R."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Peters N.R."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Kotch F."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Kotch F."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Salamat S.M."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/author | "Salamat S.M."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/22267734 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |