| http://purl.uniprot.org/citations/22269669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22269669 | http://www.w3.org/2000/01/rdf-schema#comment | "Erythroid differentiation is a tightly regulated multi-step process that has not been fully elucidated. We previously reported that a siRNA screened from random siRNA library, siRNA clone-67, induced erythroid differentiation in human erythroleukemia K-562cell line. Here we identified that human CCDC12 (coiled-coil domain containing 12) is a target of siRNA clone-67, by target capture with biotinylated siRNA. Over-expression of CCDC12 in K-562cell up-regulated the expression of CD235, ε-globin and γ-globin, accelerated cell growth, and slightly down-regulated the expression of GATA-2. Knockdown of CCDC12 slowed down the cell growth. These data indicate that CCDC12 is a new participant that promotes early erythroid differentiation."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.leukres.2011.12.017"xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/author | "Dong L."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/author | "Fan C."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/author | "Zhu N."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/name | "Leuk Res"xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/pages | "779-783"xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/title | "Isolation of siRNA target by biotinylated siRNA reveals that human CCDC12 promotes early erythroid differentiation."xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/22269669 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22269669 |
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| http://purl.uniprot.org/uniprot/J3KR35 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22269669 |