| http://purl.uniprot.org/citations/22271762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22271762 | http://www.w3.org/2000/01/rdf-schema#comment | "Apolipoprotein A-I (ApoA-I) is the main functional protein component of human high-density lipoproteins. ApoA-I shows various anti-inflammatory and atheroprotective properties toward macrophages; however, endogenous apoA-I expression has not been investigated in macrophages. We have shown that endogenous apoA-I gene is expressed in human macrophages at both mRNA and protein levels. Endogenous ApoA-I is localized in intracellular vesicles and at the external side of the plasma membrane in association with ATP-binding cassette transporter A1 (ABCA1) and lipid rafts in macrophages. We have shown that endogenous ApoA-I stabilizes ABCA1, moreover, down-regulation of ApoA-I by siRNA results in an increase of Toll-like receptor 4 (TLR4) mRNA and membrane surface protein expression, as well as an enhancement of bacterial lipopolysaccharide (LPS)-induced expression of tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), and inducible nitric oxide synthase (NOS2) genes in human macrophages. TNF-α stimulates ApoA-I expression and secretion (1.2±0.2 vs. 4.3±0.9 ng/mg total protein) in macrophages. Obtained results suggest that endogenous ApoA-I has anti-inflammatory properties, presumably due to ABCA1 stabilization in macrophages; these results elucidate the cell type-specific mechanism of the TNF-α-mediated regulation of apoA-I gene expression in monocytes and macrophages."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.11-193946"xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/author | "Ivanov A.V."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/author | "Orlov S.V."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/author | "Perevozchikov A.P."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/author | "Mogilenko D.A."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/author | "Shavva V.S."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/author | "Kudriavtsev I.V."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/author | "Trulioff A.S."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/author | "Nagumanov V.K."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/author | "Tanyanskiy D.A."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/pages | "2019-2030"xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/title | "Endogenous apolipoprotein A-I stabilizes ATP-binding cassette transporter A1 and modulates Toll-like receptor 4 signaling in human macrophages."xsd:string |
| http://purl.uniprot.org/citations/22271762 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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