| http://purl.uniprot.org/citations/22271891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22271891 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundFoxM1 has been shown to play a critical role in the pathogenesis of various epithelial malignancies. However, its role in lymphoid malignancies has not been fully clarified. We, therefore, investigated the role of FoxM1 expression in a large cohort of diffuse large B-cell lymphoma samples and panel of cell lines.Design and methodsFoxM1 expression was investigated in a large series of diffuse large B-cell lymphoma tissues in a tissue microarray format by immunohistochemistry. Apoptosis was measured by flow cytometry and protein expression was detected by immunoblotting using diffuse large B-cell lymphoma cell lines following treatment with either pharmacological inhibitor of FoxM1 or small interference RNA knockdown strategy. Invasion/migration and soft agar colony assays were also performed following treatment with FoxM1 inhibitor.ResultsFoxM1 expression was detected in 84.6% of diffuse large B-cell lymphoma tumors and found to be significantly associated with proliferative tumor marker Ki67 (P<0.0001), matrix metalloproteinases-2 (P=0.0008), matrix metalloproteinases-9 (P=0.0002), S-phase kinase associated protein-2 (P<0.0001) and inversely associated with p27 expression (P=0.0215). Expression of small interference RNA targeted against FoxM1 or treatment of diffuse large B-cell lymphoma cells with thiostrepton caused its downregulation accompanied by decreased expression of matrix metalloproteinases-2 and matrix metalloproteinases-9. Inhibition of FoxM1 in diffuse large B-cell lymphoma cells also decreased invasive and migratory capability, and induced caspase dependent apoptosis via activation of the mitochondrial apoptotic pathway. Finally, combined thiostrepton and bortezomib at sub-toxic doses led to efficient apoptosis in diffuse large B-cell lymphoma cells.ConclusionsAltogether, these results suggest that FoxM1 is over-expressed in the majority of diffuse large B-cell lymphoma samples. These data also indicate that targeting FoxM1 signaling can serve as a potential therapeutic modality in the management of diffuse large B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.org/dc/terms/identifier | "doi:10.3324/haematol.2011.053421"xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/author | "Ahmed M."xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/author | "Bavi P."xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/author | "Al-Dayel F."xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/author | "Uddin S."xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/author | "Siddiqui K."xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/author | "Al-Kuraya K.S."xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/author | "Hussain A.R."xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/name | "Haematologica"xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/pages | "1092-1100"xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/title | "Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://purl.uniprot.org/core/volume | "97"xsd:string |
| http://purl.uniprot.org/citations/22271891 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22271891 |
| http://purl.uniprot.org/citations/22271891 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22271891 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SFF0-mappedCitation-22271891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22271891 |
| http://purl.uniprot.org/uniprot/#_A0A2P9DTZ0-mappedCitation-22271891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22271891 |
| http://purl.uniprot.org/uniprot/#_A0A2P9DTZ1-mappedCitation-22271891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22271891 |
| http://purl.uniprot.org/uniprot/#_A0A2P9DTZ8-mappedCitation-22271891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22271891 |
| http://purl.uniprot.org/uniprot/#_A8K591-mappedCitation-22271891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22271891 |
| http://purl.uniprot.org/uniprot/#_Q08050-mappedCitation-22271891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22271891 |
| http://purl.uniprot.org/uniprot/#_Q53Y49-mappedCitation-22271891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22271891 |
| http://purl.uniprot.org/uniprot/A0A2P9DTZ1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22271891 |