| http://purl.uniprot.org/citations/22274711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22274711 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent findings suggest that Ring finger protein 146 (RNF146), also called iduna, have neuroprotective property due to its inhibition of Parthanatos via binding with Poly(ADP-ribose) (PAR). The Parthanatos is a PAR dependent cell death that has been implicated in many human diseases. RNF146/Iduna acts as a PARsylation-directed E3 ubquitin ligase to mediate tankyrase-dependent degradation of axin, thereby positively regulates Wnt signaling. RNF146/Iduna can also facilitate DNA repair and protect against cell death induced by DNA damaging agents or γ-irradiation. It can translocate to the nucleus after cellular injury and promote the ubiquitination and degradation of various nuclear proteins involved in DNA damage repair. The PARsylation-directed ubquitination mediated by RNF146/Iduna is analogous to the phosphorylation-directed ubquitination catalyzed by Skp1-Cul1-F-box (SCF) E3 ubiquitin complex. RNF146/Iduna has been found to be implicated in neurodegenerative disease and cancer development. Therefore modulation of the PAR-binding and PARsylation dependent E3 ligase activity of RNF146/Iduna could have therapeutic significance for diseases, in which PAR and PAR-binding proteins play key pathophysiologic roles."xsd:string |
| http://purl.uniprot.org/citations/22274711 | http://purl.org/dc/terms/identifier | "doi:10.4161/cam.5.6.18356"xsd:string |
| http://purl.uniprot.org/citations/22274711 | http://purl.uniprot.org/core/author | "Chan C.H."xsd:string |
| http://purl.uniprot.org/citations/22274711 | http://purl.uniprot.org/core/author | "Tan E.K."xsd:string |
| http://purl.uniprot.org/citations/22274711 | http://purl.uniprot.org/core/author | "Zhou Z.D."xsd:string |
| http://purl.uniprot.org/citations/22274711 | http://purl.uniprot.org/core/author | "Xiao Z.C."xsd:string |
| http://purl.uniprot.org/citations/22274711 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22274711 | http://purl.uniprot.org/core/name | "Cell Adh Migr"xsd:string |
| http://purl.uniprot.org/citations/22274711 | http://purl.uniprot.org/core/pages | "463-471"xsd:string |
| http://purl.uniprot.org/citations/22274711 | http://purl.uniprot.org/core/title | "Ring finger protein 146/Iduna is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase."xsd:string |
| http://purl.uniprot.org/citations/22274711 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/22274711 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22274711 |
| http://purl.uniprot.org/citations/22274711 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22274711 |
| http://purl.uniprot.org/uniprot/#_Q9NTX7-mappedCitation-22274711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22274711 |
| http://purl.uniprot.org/uniprot/Q9NTX7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22274711 |