| http://purl.uniprot.org/citations/22275522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22275522 | http://www.w3.org/2000/01/rdf-schema#comment | "The ribosomal stalk is formed by four acidic phosphoproteins in Saccharomyces cerevisiae, P1α, P1β, P2α and P2β, which form two heterodimers, P1α/P2β and P1β/P2α, that preferentially bind to sites A and B of the P0 protein, respectively. Using mutant strains carrying only one of the four possible P1/P2 combinations, we found a specific phenotype associated to each P1/P2 pair, indicating that not all acidic P proteins play the same role. The absence of one P1/P2 heterodimer reduced the rate of cell growth by varying degrees, depending on the proteins missing. Synthesis of the 60S ribosomal subunit also decreased, particularly in strains carrying the unusual P1α-P2α or P1β-P2β heterodimers, although the distinct P1/P2 dimers are bound with similar affinity to the mutant ribosome. While in wild-type strains the B site bound P1β/P2α in a highly specific manner and the A site bound the four P proteins similarly, both the A and B binding sites efficiently bound practically any P1/P2 pair in mutant strains expressing truncated P0 proteins. The reported results support that while most ribosomes contain a P1α/P2β-P0-P1β/P2α structure in normal conditions, the stalk assembly mechanism can generate alternative compositions, which have been previously detected in the cell."xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gks036"xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/author | "Remacha M."xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/author | "Ballesta J.P."xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/author | "Cardenas D."xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/author | "Jimenez-Diaz A."xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/author | "Camargo H."xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/author | "Revuelta-Cervantes J."xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/pages | "4520-4529"xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/title | "P1 and P2 protein heterodimer binding to the P0 protein of Saccharomyces cerevisiae is relatively non-specific and a source of ribosomal heterogeneity."xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/22275522 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22275522 |
| http://purl.uniprot.org/citations/22275522 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22275522 |
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| http://purl.uniprot.org/uniprot/#_P05319-mappedCitation-22275522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22275522 |
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| http://purl.uniprot.org/uniprot/P10622 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22275522 |