| http://purl.uniprot.org/citations/22281511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22281511 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytokine thymic stromal lymphopoietin (TSLP) functions as a regulator of bone marrow B-cell development and a key initiator of allergic inflammation. In the current study, we show that mature B cells, derived from transgenic mice with systemically elevated levels of TSLP (K5-TSLP mice), exhibit markedly enhanced mitogenic responses in vitro and that this enhanced responsiveness leads to polyclonal B-cell activation and development of autoimmune hemolytic anemia in vivo. In contrast, B cells derived from K5-TSLP mice lacking CD4(+) T cells failed to show polyclonal activation. Furthermore, neither mature B-cell activation nor hemolytic anemia occurred in IL-4-deficient K5-TSLP mice. Consistent with these findings, activation of mature B cells occurred independently of B-cell intrinsic TSLP signals. Taken together, our results demonstrate that systemic alterations in TSLP, through induction of IL-4 from CD4(+) T cells and other cell types, functions as an important factor in peripheral B-cell homeostasis and promotion of humoral autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxr113"xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/author | "Iseki M."xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/author | "Rawlings D.J."xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/author | "Ziegler S.F."xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/author | "Takaki S."xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/author | "Omori-Miyake M."xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/pages | "183-195"xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/title | "Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4."xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/22281511 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22281511 |
| http://purl.uniprot.org/citations/22281511 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22281511 |
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| http://purl.uniprot.org/uniprot/#_G3UXB0-mappedCitation-22281511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22281511 |
| http://purl.uniprot.org/uniprot/#_P07750-mappedCitation-22281511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22281511 |
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