http://purl.uniprot.org/citations/22284282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22284282 | http://www.w3.org/2000/01/rdf-schema#comment | "IntroductionCytokines and chemokines regulate bone remodeling during orthodontic tooth movement. CC chemokine ligand 2 (CCL2) is involved in osteoclast recruitment and activity, and its expression is increased in periodontal tissues under mechanical loading. In this study, we investigated whether the CC chemokine receptor 2 (CCR2)-CCL2 axis influences orthodontic tooth movement.MethodsA coil spring was placed in CCR2-deficient (CCR2(-/-)), wild-type, vehicle-treated, and P8A-treated (CCL2 analog) mice. In a histopathologic analysis, the amounts of orthodontic tooth movement and numbers of osteoclasts were determined. The expression of mediators involved in bone remodeling was evaluated by real-time polymerase chain reaction.ResultsOrthodontic tooth movement and the number of TRAP-positive cells were significantly decreased in CCR2(-/-) and P8A-treated mice in relation to wild-type and vehicle-treated mice, respectively. The expressions of RANKL, RANK, and osteoblasts markers (COL-1 and OCN) were lower in CCR2(-/-) than in wild-type mice. No significant difference was found in osteoprotegerin levels between the groups.ConclusionsThese data suggested a reduction of osteoclast and osteoblast activities in the absence of CCR2. The CCR2-CCL2 axis is positively associated with osteoclast recruitment, bone resorption, and orthodontic tooth movement. Therefore, blockage of the CCR2-CCL2 axis might be used in the future for modulating the extent of orthodontic tooth movement."xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajodo.2011.07.019"xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/author | "Teixeira M.M."xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/author | "Cunha F.d.e. Q."xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/author | "Garlet G.P."xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/author | "da Silva T.A."xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/author | "Andrade I. Jr."xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/author | "Garlet T.P."xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/author | "Queiroz-Junior C.M."xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/author | "Taddei S.R."xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/name | "Am J Orthod Dentofacial Orthop"xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/pages | "153-160"xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/title | "Role of CCR2 in orthodontic tooth movement."xsd:string |
http://purl.uniprot.org/citations/22284282 | http://purl.uniprot.org/core/volume | "141"xsd:string |
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