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http://purl.uniprot.org/citations/22285383http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22285383http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

C-type natriuretic peptide (CNP) might be an important regulator of vasodilatation, fluid and sodium balance in liver cirrhosis. We aimed at assessing its regulation and prognostic relevance in liver disease patients.

Design and methods

We analyzed NT-proCNP serum levels in 193 patients with chronic liver diseases and 43 healthy controls.

Results

Serum NT-proCNP concentrations were significantly elevated in liver disease patients compared to healthy controls, with highest levels in established hepatic cirrhosis, independent of disease etiology. NT-proCNP was associated with complications of liver diseases and portal hypertension, namely ascites, esophageal varices and hepatic encephalopathy. Circulating NT-proCNP correlated inversely with renal function. Importantly, elevated NT-proCNP levels were identified as a predictor of mortality or necessity for transplantation. NT-proCNP levels >2 pmol/L indicated adverse prognosis (sensitivity 66.7%, specificity 72.8%, RR 5.4 [95%-CI 2.6-11.2]).

Conclusions

Serum NT-proCNP is elevated in advanced liver diseases and has prognostic value in cirrhotic patients."xsd:string
http://purl.uniprot.org/citations/22285383http://purl.org/dc/terms/identifier"doi:10.1016/j.clinbiochem.2012.01.009"xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/author"Schneider C."xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/author"Trautwein C."xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/author"Koch A."xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/author"Tacke F."xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/author"Yagmur E."xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/author"Zimmermann H.W."xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/author"Baeck C."xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/name"Clin Biochem"xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/pages"429-435"xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/title"Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavorable prognosis of cirrhosis."xsd:string
http://purl.uniprot.org/citations/22285383http://purl.uniprot.org/core/volume"45"xsd:string
http://purl.uniprot.org/citations/22285383http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22285383
http://purl.uniprot.org/citations/22285383http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22285383
http://purl.uniprot.org/uniprot/#_E5LCN7-mappedCitation-22285383http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22285383
http://purl.uniprot.org/uniprot/#_P23582-mappedCitation-22285383http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22285383
http://purl.uniprot.org/uniprot/E5LCN7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22285383
http://purl.uniprot.org/uniprot/P23582http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22285383