| http://purl.uniprot.org/citations/22285439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22285439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22285439 | http://www.w3.org/2000/01/rdf-schema#comment | "The Caenorhabditis elegans distal tip cells (DTCs) are an in vivo model for the study of developmentally regulated cell migration. In this study, we characterize a novel role for CCDC-55, a conserved coiled-coil domain containing protein, in DTC migration and larval development in C. elegans. Although animals homozygous for a probable null allele, ccdc-55(ok2851), display an early larval arrest, RNAi depletion experiments allow the analysis of later phenotypes and suggest that CCDC-55 is needed within the DTC for migration to cease at the end of larval morphogenesis. The ccdc-55 gene is found in an operon with rnf-121 and rnf-5, E3 ubiquitin ligases that target cell migration genes such as the β-integrin PAT-3. Genetic interaction studies using RNAi depletion and the deletion alleles rnf-121(ok848) and rnf-5(tm794) indicate that CCDC-55 and the RNF genes act at least partially in parallel to promote termination of cell migration in the adult DTC."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mod.2012.01.003"xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mod.2012.01.003"xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/author | "Cram E.J."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/author | "Cram E.J."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/author | "Ho R."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/author | "Ho R."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/author | "Kovacevic I."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/author | "Kovacevic I."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/name | "Mech. Dev."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/name | "Mech. Dev."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/pages | "548-559"xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/pages | "548-559"xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/title | "CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/title | "CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/22285439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22285439 |
| http://purl.uniprot.org/citations/22285439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22285439 |
| http://purl.uniprot.org/citations/22285439 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22285439 |
| http://purl.uniprot.org/citations/22285439 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22285439 |