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http://purl.uniprot.org/citations/22288963http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22288963http://www.w3.org/2000/01/rdf-schema#comment"

Context

Differentiation of non-small cell carcinoma into histologic types is important because of new, successful therapies that target lung adenocarcinoma (ACA). TTF-1 is a favored marker for lung ACA but has limited sensitivity and specificity. Napsin A (Nap-A) is a functional aspartic proteinase that may be an alternative marker for primary lung ACA.

Objectives

To compare Nap-A versus TTF-1 in the typing of primary lung carcinoma and the differentiation of primary lung ACA from carcinomas of other sites.

Design

Immunohistochemistry for Nap-A and TTF-1 was performed on tissue microarrays of 1674 cases of carcinoma: 303 primary lung ACAs (18.1%), 200 primary squamous cell lung carcinomas (11.9%), 52 primary small cell carcinomas of the lung (3.1%), and carcinomas of the kidney (n  = 320; 19.1%), thyroid (n  =  96; 5.7%), biliary (n  =  89; 5.3%), bladder (n  = 47; 2.8%), breast (n  =  93; 5.6%), colon (n  =  95; 5.7%), liver (n  =  96; 5.7%), ovaries (n  =  45; 2.7%), pancreas (n  =  48; 2.9%), prostate (n  =  49; 2.9%), stomach (n  =  93; 5.6%), and uterus (n  =  48; 2.9%). Cases were evaluated against a negative control as negative, weak positive, and strong positive.

Results

Nap-A was more sensitive than TTF-1 for primary lung ACA (87% versus 64%; P < .001). Nap-A was more specific than TTF-1 for primary lung ACA versus all tumors, excluding kidney, independent of tumor type (P < .001).

Conclusions

Nap-A is superior to TTF-1 in distinguishing primary lung ACA from other carcinomas (except kidney), particularly primary lung small cell carcinoma, and primary thyroid carcinoma. A combination of Nap-A and TTF-1 is useful in the distinction of primary lung ACA (Nap-A(+), TTF-1(+)) from primary lung squamous cell carcinoma (Nap-A(-), TTF-1(-)) and primary lung small cell carcinoma (Nap-A(-), TTF-1(+))."xsd:string
http://purl.uniprot.org/citations/22288963http://purl.org/dc/terms/identifier"doi:10.5858/arpa.2011-0320-oa"xsd:string
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/author"Turner B.M."xsd:string
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/author"Fukuoka J."xsd:string
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/author"Shen S.S."xsd:string
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/author"Jagirdar J."xsd:string
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/author"Sainz I.M."xsd:string
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/author"Cagle P.T."xsd:string
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/name"Arch Pathol Lab Med"xsd:string
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/pages"163-171"xsd:string
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/title"Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarray."xsd:string
http://purl.uniprot.org/citations/22288963http://purl.uniprot.org/core/volume"136"xsd:string
http://purl.uniprot.org/citations/22288963http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22288963
http://purl.uniprot.org/citations/22288963http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22288963
http://purl.uniprot.org/uniprot/#_M0QXC5-mappedCitation-22288963http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22288963
http://purl.uniprot.org/uniprot/#_O96009-mappedCitation-22288963http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22288963
http://purl.uniprot.org/uniprot/M0QXC5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22288963
http://purl.uniprot.org/uniprot/O96009http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22288963