| http://purl.uniprot.org/citations/22290873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22290873 | http://www.w3.org/2000/01/rdf-schema#comment | "RelB and nuclear factor κB (NF-κB2) are the main effectors of NF-κB noncanonical signaling and play critical roles in many physiological processes. However, their role in hematopoietic stem/progenitor cell (HSPC) maintenance has not been characterized. To investigate this, we generated RelB/NF-κB2 double-knockout (dKO) mice and found that dKO HSPCs have profoundly impaired engraftment and self-renewal activity after transplantation into wild-type recipients. Transplantation of wild-type bone marrow cells into dKO mice to assess the role of the dKO microenvironment showed that wild-type HSPCs cycled more rapidly, were more abundant, and had developmental aberrancies: increased myeloid and decreased lymphoid lineages, similar to dKO HSPCs. Notably, when these wild-type cells were returned to normal hosts, these phenotypic changes were reversed, indicating a potent but transient phenotype conferred by the dKO microenvironment. However, dKO bone marrow stromal cell numbers were reduced, and bone-lining niche cells supported less HSPC expansion than controls. Furthermore, increased dKO HSPC proliferation was associated with impaired expression of niche adhesion molecules by bone-lining cells and increased inflammatory cytokine expression by bone marrow cells. Thus, RelB/NF-κB2 signaling positively and intrinsically regulates HSPC self-renewal and maintains stromal/osteoblastic niches and negatively and extrinsically regulates HSPC expansion and lineage commitment through the marrow microenvironment."xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.org/dc/terms/identifier | "doi:10.1002/stem.1050"xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/author | "Morita Y."xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/author | "Zhao C."xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/author | "Xing L."xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/author | "Xiu Y."xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/author | "Jordan C.T."xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/author | "Boyce B.F."xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/author | "Ashton J."xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/name | "Stem Cells"xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/pages | "709-718"xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/title | "Noncanonical NF-kappaB signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions."xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/22290873 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22290873 |
| http://purl.uniprot.org/citations/22290873 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22290873 |
| http://purl.uniprot.org/uniprot/#_A0A140LI24-mappedCitation-22290873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22290873 |
| http://purl.uniprot.org/uniprot/#_A0A140LI46-mappedCitation-22290873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22290873 |
| http://purl.uniprot.org/uniprot/#_A0A140LJD6-mappedCitation-22290873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22290873 |
| http://purl.uniprot.org/uniprot/#_A0A494B9Y5-mappedCitation-22290873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22290873 |
| http://purl.uniprot.org/uniprot/#_A0A494BAQ2-mappedCitation-22290873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22290873 |
| http://purl.uniprot.org/uniprot/#_Q3UV15-mappedCitation-22290873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22290873 |
| http://purl.uniprot.org/uniprot/#_Q4U105-mappedCitation-22290873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22290873 |
| http://purl.uniprot.org/uniprot/#_Q4U106-mappedCitation-22290873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22290873 |