| http://purl.uniprot.org/citations/22300504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22300504 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhalation of toxic doses of ozone is associated with a sterile inflammatory response characterized by an accumulation of macrophages in the lower lung which are activated to release cytotoxic/proinflammatory mediators that contribute to tissue injury. Toll-like receptor 4 (TLR4) is a pattern recognition receptor present on macrophages that has been implicated in sterile inflammatory responses. In the present studies we used TLR4 mutant C3H/HeJ mice to analyze the role of TLR4 in ozone-induced lung injury, oxidative stress and inflammation. Acute exposure of control C3H/HeOuJ mice to ozone (0.8ppm for 3h) resulted in increases in bronchoalveolar lavage (BAL) lipocalin 24p3 and 4-hydroxynonenal modified protein, markers of oxidative stress and lipid peroxidation. This was correlated with increases in BAL protein, as well as numbers of alveolar macrophages. Levels of surfactant protein-D, a pulmonary collectin known to regulate macrophage inflammatory responses, also increased in BAL following ozone inhalation. Ozone inhalation was associated with classical macrophage activation, as measured by increased NF-κB binding activity and expression of TNFα mRNA. The observation that these responses to ozone were not evident in TLR4 mutant C3H/HeJ mice demonstrates that functional TLR4 contributes to ozone-induced sterile inflammation and macrophage activation."xsd:string |
| http://purl.uniprot.org/citations/22300504 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexmp.2012.01.004"xsd:string |
| http://purl.uniprot.org/citations/22300504 | http://purl.uniprot.org/core/author | "Laskin J.D."xsd:string |
| http://purl.uniprot.org/citations/22300504 | http://purl.uniprot.org/core/author | "Laskin D.L."xsd:string |
| http://purl.uniprot.org/citations/22300504 | http://purl.uniprot.org/core/author | "Connor A.J."xsd:string |
| http://purl.uniprot.org/citations/22300504 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22300504 | http://purl.uniprot.org/core/name | "Exp Mol Pathol"xsd:string |
| http://purl.uniprot.org/citations/22300504 | http://purl.uniprot.org/core/pages | "229-235"xsd:string |
| http://purl.uniprot.org/citations/22300504 | http://purl.uniprot.org/core/title | "Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4."xsd:string |
| http://purl.uniprot.org/citations/22300504 | http://purl.uniprot.org/core/volume | "92"xsd:string |
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