| http://purl.uniprot.org/citations/22301135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22301135 | http://www.w3.org/2000/01/rdf-schema#comment | "The antiviral factor CPSF6-358 restricts human immunodeficiency virus type 1 (HIV-1) infection through an interaction with capsid (CA), preventing virus nuclear entry and integration. HIV-1 acquires resistance to CPSF6-358 through an N74D mutation of CA that impairs binding of the antiviral factor. Here we examined the determinants within CPSF6-358 that are necessary for CA-specific interaction. Residues 314 to 322 include amino acids that are essential for CPSF6-358 restriction of HIV-1. Fusion of CPSF6 residues 301 to 358 to rhesus TRIM5α is also sufficient to restrict wild-type but not N74D HIV-1. Restriction is lost if CPSF6 residues in the amino acid 314 to 322 interaction motif are mutated. Examination of the CA targeting motif in CPSF6-358 did not reveal evidence of positive selection. Given the sensitivity of different primate lentiviruses to CPSF6-358 and apparent conservation of this interaction, our data suggest that CPSF6-358-mediated targeting of HIV-1 could provide a broadly effective antiviral strategy."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.06607-11"xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/author | "Lee K."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/author | "Kewalramani V.N."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/author | "Martin T.D."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/author | "Sawyer S.L."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/author | "Choi L."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/author | "Meyerson N.R."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/author | "Mulky A."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/author | "Yuen W."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/pages | "3851-3860"xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/title | "HIV-1 capsid-targeting domain of cleavage and polyadenylation specificity factor 6."xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/22301135 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22301135 |
| http://purl.uniprot.org/citations/22301135 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22301135 |
| http://purl.uniprot.org/uniprot/#_B4DSU9-mappedCitation-22301135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22301135 |
| http://purl.uniprot.org/uniprot/#_Q16630-mappedCitation-22301135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22301135 |
| http://purl.uniprot.org/uniprot/#_L8E8D6-mappedCitation-22301135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22301135 |
| http://purl.uniprot.org/uniprot/B4DSU9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22301135 |
| http://purl.uniprot.org/uniprot/Q16630 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22301135 |
| http://purl.uniprot.org/uniprot/L8E8D6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22301135 |