| http://purl.uniprot.org/citations/22302993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22302993 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously found that the NF-κB transcription factor is activated during the recovery period after heat shock; moreover, we demonstrated that NF-κB is essential for cell survival after heat shock by activating autophagy, a mechanism that probably helps the cell to cope with hyperthermic stress through clearance of damaged proteins. In this study, we analyze the involvement of NF-κB in basal and heat-stress-induced protein quality control, by comparing the level of multiubiquitylated and/or aggregated proteins, and proteasome and autophagic activity in NF-κB-competent and NF-κB-incompetent cells. We show that NF-κB has only a minor role in basal protein quality control, where it modulates autophagosome maturation. By contrast, NF-κB is shown to be a key player in protein quality control after hyperthermia. Indeed, NF-κB-incompetent cells show highly increased levels of multiubiquitylated and/or aggregated proteins and aggresome clearance defects; a phenotype that disappears when NF-κB activity is restored to normal. We demonstrate that during heat shock recovery NF-κB activates selective removal of misfolded or aggregated proteins--a process also called 'aggrephagy'--by controlling the expression of BAG3 and HSPB8 and by modulating the level of the BAG3-HspB8 complex. Thus NF-κB-mediated increase in the level of the BAG3-HspB8 complex leads to upregulation of aggrephagy and clearance of irreversibly damaged proteins and might increase cell survival in conditions of hyperthermia."xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.091041"xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/author | "Richet E."xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/author | "Guyot B."xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/author | "Arrigo A.P."xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/author | "Kretz-Remy C."xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/author | "Nivon M."xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/author | "Abou-Samra M."xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/pages | "1141-1151"xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/title | "NF-kappaB regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex."xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/22302993 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22302993 |
| http://purl.uniprot.org/citations/22302993 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22302993 |
| http://purl.uniprot.org/uniprot/#_A0A087X0W8-mappedCitation-22302993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22302993 |
| http://purl.uniprot.org/uniprot/#_A0A872G2N3-mappedCitation-22302993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22302993 |
| http://purl.uniprot.org/uniprot/#_A0A872G2N7-mappedCitation-22302993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22302993 |
| http://purl.uniprot.org/uniprot/#_B4E082-mappedCitation-22302993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22302993 |
| http://purl.uniprot.org/uniprot/#_L0R6N5-mappedCitation-22302993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22302993 |
| http://purl.uniprot.org/uniprot/#_Q53GY1-mappedCitation-22302993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22302993 |
| http://purl.uniprot.org/uniprot/#_Q2TAM5-mappedCitation-22302993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22302993 |
| http://purl.uniprot.org/uniprot/#_O95817-mappedCitation-22302993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22302993 |
| http://purl.uniprot.org/uniprot/#_P78359-mappedCitation-22302993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22302993 |