| http://purl.uniprot.org/citations/22304922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22304922 | http://www.w3.org/2000/01/rdf-schema#comment | "Growing axons encounter multiple guidance cues, but it is unclear how separate signals are resolved and integrated into coherent instructions for growth cone navigation. We report that glycosylphosphatidylinositol (GPI)-anchored ephrin-As function as "reverse" signaling receptors for motor axons when contacted by transmembrane EphAs present in the dorsal limb. Ephrin-A receptors are thought to depend on transmembrane coreceptors for transmitting signals intracellularly. We show that the receptor tyrosine kinase Ret is required for motor axon attraction mediated by ephrin-A reverse signaling. Ret also mediates GPI-anchored GFRα1 signaling in response to GDNF, a diffusible chemoattractant in the limb, indicating that Ret is a multifunctional coreceptor for guidance molecules. Axons respond synergistically to coactivation by GDNF and EphA ligands, and these cooperative interactions are gated by GFRα1 levels. Our studies uncover a hierarchical GPI-receptor signaling network that is constructed from combinatorial components and integrated through Ret using ligand coincidence detection."xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.01.024"xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/author | "Marquardt T."xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/author | "Bai G."xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/author | "Pierchala B.A."xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/author | "Pfaff S.L."xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/author | "Bonanomi D."xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/author | "Lettieri K."xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/author | "Chivatakarn O."xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/author | "Abdesselem H."xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/pages | "568-582"xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/title | "Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals."xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://purl.uniprot.org/core/volume | "148"xsd:string |
| http://purl.uniprot.org/citations/22304922 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22304922 |
| http://purl.uniprot.org/citations/22304922 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22304922 |
| http://purl.uniprot.org/uniprot/#_A0A087WNT5-mappedCitation-22304922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22304922 |
| http://purl.uniprot.org/uniprot/#_A0A097BVN3-mappedCitation-22304922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22304922 |
| http://purl.uniprot.org/uniprot/#_A0A286YCV8-mappedCitation-22304922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22304922 |
| http://purl.uniprot.org/uniprot/#_A0A286YDA0-mappedCitation-22304922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22304922 |
| http://purl.uniprot.org/uniprot/#_A0A286YDA3-mappedCitation-22304922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22304922 |
| http://purl.uniprot.org/uniprot/#_A0A087WQW6-mappedCitation-22304922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22304922 |
| http://purl.uniprot.org/uniprot/#_A0A087WQZ6-mappedCitation-22304922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22304922 |