http://purl.uniprot.org/citations/22305102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22305102 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo examine the relevance of growth differentiation factor 3 (GDF-3) and bone morphogenetic protein (BMP) cytokines in human ovary.DesignMolecular studies.SettingResearch laboratory.Patient(s)Eight women undergoing salpingo-oophorectomy and 30 women undergoing ovarian stimulation for in vitro fertilization.Intervention(s)Localizing GDF-3 protein in human ovaries; granulosa cells (GC) cultured with GDF-3, BMP-6, or BMP-7 followed by RNA extraction.Main outcome measure(s)The localization of GDF-3 protein in normal human ovaries via immunohistochemical analysis, GDF-3 messenger RNA (mRNA) expression evaluation via quantitative real-time reverse transcription and polymerase chain reaction (RT-PCR), and evaluation of the effect of GDF-3 on leuteinizing hormone (LH) receptor mRNA expression via quantitative real-time RT-PCR.Result(s)In the ovary, BMP cytokines, of the transforming growth factor beta (TGF-β) superfamily, are known as a luteinization inhibitor by suppressing LH receptor expression in GC. Growth differentiation factor 3, a TGF-β superfamily cytokine, is recognized as an inhibitor of BMP cytokines in other cells. Immunohistochemical analysis showed that GDF-3 was strongly detected in the GC of antral follicles. An in vitro assay revealed that BMP-6 or BMP-7 induced GDF-3 mRNA in GC. Also, GDF-3 increased LH receptor mRNA expression and inhibited the effect of BMP-7, which suppressed the LH receptor mRNA expression in GC.Conclusion(s)GDF-3, induced with BMP-6 and BMP-7, might play a role in folliculogenesis by inhibiting the effect of BMP cytokines."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.fertnstert.2012.01.100"xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/author | "Harada M."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/author | "Yano T."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/author | "Taketani Y."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/author | "Koga K."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/author | "Osuga Y."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/author | "Fujimoto A."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/author | "Akiyama I."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/author | "Yoshino O."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/name | "Fertil Steril"xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/pages | "979-983"xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/title | "Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells."xsd:string |
http://purl.uniprot.org/citations/22305102 | http://purl.uniprot.org/core/volume | "97"xsd:string |
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