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| http://purl.uniprot.org/citations/22306662 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous studies of nucleosome positioning have shown that nucleosomes almost invariably adopt one of several alternative overlapping positions on a short DNA fragment in vitro. We define such a set of overlapping positions as a "position cluster", and the 5S RNA gene positioning sequence is presented as an example. The notable exception is the synthetic 601-sequence, which can position a nucleosome perfectly in vitro, though not in vivo. Many years ago, we demonstrated that nucleosome position clusters are present on the CUP1 and HIS3 genes in native yeast chromatin. Recently, using genome-wide paired-end sequencing of nucleosomes, we have shown that position clusters are the general rule in yeast chromatin, not the exception. We argue that, within a cell population, one of several alternative nucleosomal arrays is formed on each gene. We show how position clusters and alternative arrays can give rise to typical nucleosome occupancy profiles, and that position clusters are disrupted by transcriptional activation. The centromeric nucleosome is a rare example of perfect positioning in vivo. It is, however, a special case, since it contains the centromeric histone H3 variant instead of normal H3. Perfect positioning might be due to centromeric sequence-specific DNA binding proteins. Finally, we point out that the existence of position clusters implies that the putative nucleosome code is degenerate. We suggest that degeneracy might be a crucial point in the debate concerning the code. This article is part of a Special Issue entitled: Chromatin in time and space."xsd:string |
| http://purl.uniprot.org/citations/22306662 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbagrm.2012.01.008"xsd:string |
| http://purl.uniprot.org/citations/22306662 | http://purl.uniprot.org/core/author | "Clark D.J."xsd:string |
| http://purl.uniprot.org/citations/22306662 | http://purl.uniprot.org/core/author | "Nagarajavel V."xsd:string |
| http://purl.uniprot.org/citations/22306662 | http://purl.uniprot.org/core/author | "Cole H.A."xsd:string |
| http://purl.uniprot.org/citations/22306662 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22306662 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/22306662 | http://purl.uniprot.org/core/pages | "639-643"xsd:string |
| http://purl.uniprot.org/citations/22306662 | http://purl.uniprot.org/core/title | "Perfect and imperfect nucleosome positioning in yeast."xsd:string |
| http://purl.uniprot.org/citations/22306662 | http://purl.uniprot.org/core/volume | "1819"xsd:string |
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