| http://purl.uniprot.org/citations/22307584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22307584 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor metastasis to bone is a serious pathological situation that causes severe pain, and deterioration in locomoter function. However, the mechanisms underlying tumor metastasis is still incompletely understood. CIZ/NMP4 is a nucleocytoplasmic shuttling protein and its roles in tumor cells have not been known. We, therefore, hypothesized the role of CIZ/NMP4 in B16 melanoma cells that metastasize to bone. CIZ/NMP4 is expressed in B16 cells. The CIZ/NMP4 expression levels are correlated to the metastatic activity in divergent types of melanoma cells. Overexpression of CIZ/NMP4 increased B16 cell migration in Trans-well assay. Conversely, siRNA-based knockdown of CIZ/NMP4 suppressed migratory activity of these cells. As RANKL promotes metastasis of tumor cells in bone, we tested its effect on CIZ in melanoma cells. RANKL treatment enhanced CIZ/NMP4 expression. This increase of CIZ by RANKL promoted migration. Conversely, we identified CIZ/NMP4 binding site in the promoter of RANKL. Furthermore, luciferase assay indicated that CIZ/NMP4 overexpression enhanced RANKL promoter activities, revealing a positive feedback loop of CIZ/NMP4 and RANKL in melanoma. These observations indicate that CIZ/NMP4 is critical regulator of metastasis of melanoma cells."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.24066"xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/author | "Hemmi H."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/author | "Nakamoto T."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/author | "Sakuma T."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/author | "Amagasa T."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/author | "Ezura Y."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/author | "Kitazawa R."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/author | "Kitazawa S."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/author | "Hayata T."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/author | "Notomi T."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/pages | "2807-2812"xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/title | "CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells."xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://purl.uniprot.org/core/volume | "227"xsd:string |
| http://purl.uniprot.org/citations/22307584 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22307584 |
| http://purl.uniprot.org/citations/22307584 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22307584 |
| http://purl.uniprot.org/uniprot/#_E9Q1A5-mappedCitation-22307584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22307584 |
| http://purl.uniprot.org/uniprot/#_A9X426-mappedCitation-22307584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22307584 |
| http://purl.uniprot.org/uniprot/#_A9X427-mappedCitation-22307584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22307584 |
| http://purl.uniprot.org/uniprot/#_E9QAR1-mappedCitation-22307584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22307584 |
| http://purl.uniprot.org/uniprot/#_E9QAR4-mappedCitation-22307584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22307584 |