| http://purl.uniprot.org/citations/22307793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22307793 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon regulatory factor 3 (IRF-3), an essential transcriptional regulator of the interferon genes, plays an important role in host defense against viral and microbial infection as well as in cell growth regulation. Promoter plays a crucial role in gene transcription. We have reported the characterization of the wide type of human IRF-3 promoter, but the characterization of the spliced variant of human IRF-3 Int2V1 promoter has not been systematically analyzed. To observe the spliced variant of human IRF-3 promoter, we have cloned the human IRF-3 gene promoter region containing 300 nucleotides upstream the transcription start site (TSS). Transient transfection of 5' deleted promoter-reporter constructs and luciferase assay illustrated the region -159/-100 relative to the TSS is sufficient for full promoter activity. This region contains GATA1 and specific protein-1 (Sp1) transcription factor binding sites. Interestingly, mutation of this Sp1 site reduced the promoter activity by 50%. However, overexpression of Sp1 increased the transcription activity by 2.4-fold. These results indicated that the spliced variant of human IRF-3 gene core promoter was located within the region -159/-100 relative to the TSS. Sp1 transcription factor upregulates the spliced variant of human IRF-3 gene promoter."xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11033-012-1528-9"xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://purl.uniprot.org/core/author | "Jin R."xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://purl.uniprot.org/core/author | "Ren W."xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://purl.uniprot.org/core/author | "Zhu L.H."xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://purl.uniprot.org/core/author | "Zhou G.P."xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://purl.uniprot.org/core/author | "Xu H.G."xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22307793 | http://purl.uniprot.org/core/name | "Mol Biol Rep"xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://purl.uniprot.org/core/pages | "6987-6993"xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://purl.uniprot.org/core/title | "Characterization of a spliced variant of human IRF-3 promoter and its regulation by the transcription factor Sp1."xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/22307793 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22307793 |
| http://purl.uniprot.org/citations/22307793 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22307793 |
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| http://purl.uniprot.org/uniprot/#_B2R4Y6-mappedCitation-22307793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22307793 |
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