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Aim

We investigated the angiogenesis and density of newly formed blood vessels in embryonal tumors in relation to Ki-67, bcl-2, p-53 and p-27 expression.

Methods

Forty-five children with embryonal tumors were enrolled in the study. Forty patients had a medulloblastoma (MB) and 5 patients had atypical teratoid/rhabdoid tumor (AT/RT).

Results

In MB, the 5-year PFS and OS was 62.5 and 70%, respectively. Patients with Ki-67 index >50%, bcl-2 index >30% and higher density of new vessels were associated with worse survival. In the multivariate analysis, Ki-67 index was identified as a factor with independent prognostic power. In AT/RTs, high density of new vessels (>25 HRF) was observed in 3 patients and Ki-67 index over 25% was found in 4 patients.

Conclusion

Increased Ki-67, bcl-2 and density of new vessels are of prognostic value for the disease outcome in MB."xsd:string
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http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/author"Stefanaki K."xsd:string
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/author"Moschovi M."xsd:string
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/author"Alexiou G.A."xsd:string
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/author"Prodromou N."xsd:string
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/author"Koultouki E."xsd:string
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/author"Sfakianos G."xsd:string
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/author"Tourkantoni N."xsd:string
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/name"Pediatr Neurosurg"xsd:string
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/pages"241-247"xsd:string
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/title"Prognostic significance of angiogenesis in relation to Ki-67, p-53, p-27, and bcl-2 expression in embryonal tumors."xsd:string
http://purl.uniprot.org/citations/22309998http://purl.uniprot.org/core/volume"47"xsd:string
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