| http://purl.uniprot.org/citations/22314363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22314363 | http://www.w3.org/2000/01/rdf-schema#comment | "Eph receptors are implicated in regulating the malignant progression of cancer. Here we find that despite overexpression of EphB3 in human non-small-cell lung cancer, as reported previously, the expression of its cognate ligands, either ephrin-B1 or ephrin-B2, is significantly downregulated, leading to reduced tyrosine phosphorylation of EphB3. Forced activation of EphB3 kinase in EphB3-overexpressing non-small-cell lung cancer cells inhibits cell migratory capability in vitro as well as metastatic seeding in vivo. Furthermore, we identify a novel EphB3-binding protein, the receptor for activated C-kinase 1, which mediates the assembly of a ternary signal complex comprising protein phosphatase 2A, Akt and itself in response to EphB3 activation, leading to reduced Akt phosphorylation and subsequent inhibition of cell migration. Our study reveals a novel tumour-suppressive signalling pathway associated with kinase-activated EphB3 in non-small-cell lung cancer, and provides a potential therapeutic strategy by activating EphB3 signalling, thus inhibiting tumour metastasis."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms1675"xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Shi S."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Xie D."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Sun Z.J."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Li J.J."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Zhu Y.Q."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Deng Y.Z."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Xu J.F."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Feng Y.X."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Zhao J.S."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/author | "Ji X.D."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/pages | "667"xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/title | "EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex."xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/22314363 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22314363 |
| http://purl.uniprot.org/citations/22314363 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22314363 |
| http://purl.uniprot.org/uniprot/#_B3KVH4-mappedCitation-22314363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22314363 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D6-mappedCitation-22314363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22314363 |