| http://purl.uniprot.org/citations/22315446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22315446 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 2 diabetes is characterized by diminished pancreatic β-cell mass and function. Glucagon-like peptide-1 has been reported to increase islet cell proliferation and reduce apoptosis of β-cells in rodents. In this study, we explored the effect of chronic administration of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance, β-cell function, and β-cell mass in Irs2-knockout (Irs2(-/-)) mice. Wild-type and Irs2(-/-) mice were fed a high-fat diet for 20 wk, with or without vildagliptin. In both genotypes of mice, vildagliptin significantly decreased the area under the curve (0-120 min) of blood glucose and increased the insulin response to glucose during the oral glucose tolerance test. In the oral glucose tolerance test performed 1 d after discontinuation of vildagliptin administration, the area under the curve (0-120 min) of blood glucose was still significantly decreased and the insulin response to glucose was significantly increased in the Irs2(-/-) mice treated with vildagliptin as compared with the values in the mice not treated with vildagliptin. Histochemical analysis of the pancreatic islets revealed significant increase of the β-cell mass and decrease in the proportion of terminal deoxynucleotidyl transferase dUTP nick end labeling-positive β-cells but no significant increase of the bromodeoxyuridine incorporation in Irs2(-/-) mice treated with vildagliptin. Our results suggest that vildagliptin improved glucose tolerance and increased the β-cell mass by reducing β-cell apoptosis in the Irs2(-/-) mice, and that the reduction of β-cell apoptosis by vildagliptin was independent of the Irs2 expression in the cells."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2011-1712"xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/author | "Nakamura A."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/author | "Kadowaki T."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/author | "Kubota N."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/author | "Terauchi Y."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/author | "Shinoda K."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/author | "Shirakawa J."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/author | "Togashi Y."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/author | "Muraoka T."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/author | "Orime K."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/pages | "1093-1102"xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/title | "Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and beta-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet."xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://purl.uniprot.org/core/volume | "153"xsd:string |
| http://purl.uniprot.org/citations/22315446 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22315446 |
| http://purl.uniprot.org/citations/22315446 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22315446 |
| http://purl.uniprot.org/uniprot/#_P28843-mappedCitation-22315446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22315446 |
| http://purl.uniprot.org/uniprot/#_O88970-mappedCitation-22315446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22315446 |
| http://purl.uniprot.org/uniprot/#_P81122-mappedCitation-22315446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22315446 |
| http://purl.uniprot.org/uniprot/#_Q3TR43-mappedCitation-22315446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22315446 |
| http://purl.uniprot.org/uniprot/#_Q3U2I0-mappedCitation-22315446 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22315446 |