| http://purl.uniprot.org/citations/22318714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22318714 | http://www.w3.org/2000/01/rdf-schema#comment | "Abnormal expression of histone demethylase Jumonji domain-containing protein 1A (JMJD1A) is associated with many kinds of cancers. JMJD1A is also a hypoxic response gene and its expression is regulated by hypoxia-inducible factor-1α (HIF-1α). In this study, we determined the role of JMJD1A in development and hypoxia pathway. We also measured the expression of JMJD1A and two hypoxia factors glucose transporter 1 (GLUT1) and vascular endothelial growth factor (VEGF) in 786-0 and HEK293 cells treated with different concentrations of NiCl(2) (2.5-100 μM) for 24 h, and found that JMJD1A mRNA and protein were up-regulated with increased concentrations of NiCl(2). We then observed that ascorbate could retard the up-regulated effect of NiCl(2)-induced JMJD1A expression in a dose-dependent manner through decreasing the stability of HIF-1α protein. Immunohistochemical analysis further demonstrated ascorbate antagonized Ni(2+)-induced up-regulation of JMJD1A expression in 786-0, HEK293, and OS-RC-2 cells. These findings suggest that both Ni(2+) and ascorbate can regulate the expression of histone demethylase JMJD1A, which is important for cancer development or inhibition."xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.org/dc/terms/identifier | "doi:10.1093/abbs/gms004"xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/author | "Cai Z."xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/author | "Duan X."xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/author | "Gui Y."xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/name | "Acta Biochim Biophys Sin (Shanghai)"xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/pages | "330-338"xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/title | "Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells."xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/22318714 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22318714 |
| http://purl.uniprot.org/citations/22318714 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22318714 |
| http://purl.uniprot.org/uniprot/#_B4E2H5-mappedCitation-22318714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22318714 |
| http://purl.uniprot.org/uniprot/#_Q9Y4C1-mappedCitation-22318714 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22318714 |
| http://purl.uniprot.org/uniprot/Q9Y4C1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22318714 |
| http://purl.uniprot.org/uniprot/B4E2H5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22318714 |