| http://purl.uniprot.org/citations/22322944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22322944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22322944 | http://www.w3.org/2000/01/rdf-schema#comment | "The proteins Ctf19, Okp1, Mcm21 and Ame1 are the components of COMA, a subassembly of budding-yeast kinetochores. We have determined the crystal structure of a conserved COMA subcomplex--the Ctf19-Mcm21 heterodimer--from Kluyveromyces lactis. Both proteins contain 'double-RWD' domains, which together form a Y-shaped framework with flexible N-terminal extensions. The kinetochore proteins Csm1, Spc24 and Spc25 have related single RWD domains, and Ctf19 and Mcm21 associate with pseudo-twofold symmetry analogous to that in the Csm1 homodimer and the Spc24-Spc25 heterodimer. The double-RWD domain core of the Ctf19-Mcm21 heterodimer is sufficient for association with Okp1-Ame1; the less conserved N-terminal regions may interact with components of a more extensive 'CTF19 complex'. Our structure shows the RWD domain to be a recurring module of kinetochore architecture that may be present in other kinetochore substructures. Like many eukaryotic molecular machines, kinetochores may have evolved from simpler assemblies by multiplication of a few ancestral modules."xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2012.1"xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2012.1"xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/author | "Harrison S.C."xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/author | "Harrison S.C."xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/author | "Schmitzberger F."xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/author | "Schmitzberger F."xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/pages | "216-222"xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/pages | "216-222"xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/title | "RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure."xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/title | "RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure."xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22322944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22322944 |
| http://purl.uniprot.org/citations/22322944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22322944 |
| http://purl.uniprot.org/citations/22322944 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22322944 |
| http://purl.uniprot.org/citations/22322944 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22322944 |
| http://purl.uniprot.org/uniprot/Q6CVQ9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/22322944 |
| http://purl.uniprot.org/uniprot/Q6CRN7 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/22322944 |