| http://purl.uniprot.org/citations/22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22323604 | http://www.w3.org/2000/01/rdf-schema#comment | "Although aberrant microRNA (miRNA) expression is linked to human diseases including cancer, the mechanisms that regulate the expression of each individual miRNA remain largely unknown. TAR DNA-binding protein-43 (TDP-43) is homologous to the heterogeneous nuclear ribonucleoproteins (hnRNPs), which are involved in RNA processing, and its abnormal cellular distribution is a key feature of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two neurodegenerative diseases. Here, we show that TDP-43 facilitates the production of a subset of precursor miRNAs (pre-miRNAs) by both interacting with the nuclear Drosha complex and binding directly to the relevant primary miRNAs (pri-miRNAs). Furthermore, cytoplasmic TDP-43, which interacts with the Dicer complex, promotes the processing of some of these pre-miRNAs via binding to their terminal loops. Finally, we show that involvement of TDP-43 in miRNA biogenesis is indispensable for neuronal outgrowth. These results support a previously uncharacterized role for TDP-43 in posttranscriptional regulation of miRNA expression in both the nucleus and the cytoplasm."xsd:string |
| http://purl.uniprot.org/citations/22323604 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1112427109"xsd:string |
| http://purl.uniprot.org/citations/22323604 | http://purl.uniprot.org/core/author | "Kawahara Y."xsd:string |
| http://purl.uniprot.org/citations/22323604 | http://purl.uniprot.org/core/author | "Mieda-Sato A."xsd:string |
| http://purl.uniprot.org/citations/22323604 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22323604 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22323604 | http://purl.uniprot.org/core/pages | "3347-3352"xsd:string |
| http://purl.uniprot.org/citations/22323604 | http://purl.uniprot.org/core/title | "TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes."xsd:string |
| http://purl.uniprot.org/citations/22323604 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22323604 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22323604 |
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| http://purl.uniprot.org/uniprot/#_A0A087WQ63-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |
| http://purl.uniprot.org/uniprot/#_A0A087WQA5-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MSV7-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |
| http://purl.uniprot.org/uniprot/#_A0A0A0N0L3-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |
| http://purl.uniprot.org/uniprot/#_A0A087WNY6-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |
| http://purl.uniprot.org/uniprot/#_A0A087WP57-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |
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| http://purl.uniprot.org/uniprot/#_A0A087WS17-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |
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| http://purl.uniprot.org/uniprot/#_A0A087WSC6-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |
| http://purl.uniprot.org/uniprot/#_A0A087WSE4-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |
| http://purl.uniprot.org/uniprot/#_A0A087WSH7-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |
| http://purl.uniprot.org/uniprot/#_A0A087WQT4-mappedCitation-22323604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323604 |