| http://purl.uniprot.org/citations/22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22323706 | http://www.w3.org/2000/01/rdf-schema#comment | "Memories for emotionally arousing experiences are typically vivid and persistent. The recurrent, intrusive memories of traumatic events in post-traumatic stress disorder (PTSD) are an extreme example. Stress-responsive neurotransmitters released during emotional arousal are proposed to enhance the consolidation of fear memory. These transmitters may include norepinephrine and epinephrine (NE/E) because stimulating β-adrenergic receptors shortly after training can enhance memory consolidation. However, mice lacking NE/E acquire and consolidate fear memory normally. Here, we show by using pharmacologic and genetic manipulations in mice and rats that NE/E are not essential for classical fear memory consolidation because signaling by the β(2)-adrenergic receptor is redundant with signaling by dopamine at the D(5)-dopaminergic receptor. The intracellular signaling that is stimulated by these receptors to promote consolidation uses distinct G proteins to redundantly activate phospholipase C. The results support recent evidence indicating that blocking β-adrenergic receptors alone shortly after trauma may not be sufficient to prevent PTSD."xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5231-11.2012"xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://purl.uniprot.org/core/author | "Young M.B."xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://purl.uniprot.org/core/author | "Ouyang M."xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://purl.uniprot.org/core/author | "Thomas S.A."xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://purl.uniprot.org/core/author | "Schutsky K."xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://purl.uniprot.org/core/author | "Lestini M.M."xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22323706 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://purl.uniprot.org/core/pages | "1932-1941"xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://purl.uniprot.org/core/title | "Redundant catecholamine signaling consolidates fear memory via phospholipase C."xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22323706 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22323706 |
| http://purl.uniprot.org/citations/22323706 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22323706 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VK92-mappedCitation-22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323706 |
| http://purl.uniprot.org/uniprot/#_B2RQS5-mappedCitation-22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323706 |
| http://purl.uniprot.org/uniprot/#_F8UX47-mappedCitation-22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323706 |
| http://purl.uniprot.org/uniprot/#_P18762-mappedCitation-22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323706 |
| http://purl.uniprot.org/uniprot/#_Q64237-mappedCitation-22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323706 |
| http://purl.uniprot.org/uniprot/#_Q8BLD9-mappedCitation-22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323706 |
| http://purl.uniprot.org/uniprot/#_P34971-mappedCitation-22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323706 |
| http://purl.uniprot.org/uniprot/#_Q61616-mappedCitation-22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323706 |
| http://purl.uniprot.org/uniprot/#_Q80T33-mappedCitation-22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323706 |
| http://purl.uniprot.org/uniprot/#_Q8K0V0-mappedCitation-22323706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22323706 |