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http://purl.uniprot.org/citations/22326224http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22326224http://www.w3.org/2000/01/rdf-schema#comment"Progress has been made in elucidating the cell-surface phenotype of primary adipose progenitors; however, specific functional markers and distinct molecular signatures of fat depot-specific preadipocytes have remained elusive. In this study, we label committed murine adipose progenitors through expression of GFP from the genetic locus for Zfp423, a gene controlling preadipocyte determination. Selection of GFP-expressing fibroblasts from either subcutaneous or visceral adipose-derived stromal vascular cultures isolates stably committed preadipocytes that undergo robust adipogenesis. Immunohistochemistry for Zfp423-driven GFP expression in vivo confirms a perivascular origin of preadipocytes within both white and brown adipose tissues. Interestingly, a small subset of capillary endothelial cells within white and brown fat also express this marker, suggesting a contribution of specialized endothelial cells to the adipose lineage. Zfp423(GFP) mice represent a simple tool for the specific localization and isolation of molecularly defined preadipocytes from distinct adipose tissue depots."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.org/dc/terms/identifier"doi:10.1016/j.cmet.2012.01.010"xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Ye L."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Spiegelman B.M."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Cohen P."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Gupta R.K."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Lo J.C."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Cinti S."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Frontini A."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Kleiner S."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Khandekar M.J."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Mepani R.J."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/author"Bhowmick D.C."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/name"Cell Metab"xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/pages"230-239"xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/title"Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells."xsd:string
http://purl.uniprot.org/citations/22326224http://purl.uniprot.org/core/volume"15"xsd:string
http://purl.uniprot.org/citations/22326224http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22326224
http://purl.uniprot.org/citations/22326224http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22326224
http://purl.uniprot.org/uniprot/#_G3UYI9-mappedCitation-22326224http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22326224
http://purl.uniprot.org/uniprot/#_G3UZP1-mappedCitation-22326224http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22326224
http://purl.uniprot.org/uniprot/#_G3UW89-mappedCitation-22326224http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22326224
http://purl.uniprot.org/uniprot/#_Q3V017-mappedCitation-22326224http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22326224