| http://purl.uniprot.org/citations/22326953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22326953 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long-term survival of patients with AML has changed little over the past decade, necessitating the identification and validation of new AML targets. Integration of genomic approaches with small-molecule and genetically based high-throughput screening holds the promise of improved discovery of candidate targets for cancer therapy. Here, we identified a role for glycogen synthase kinase 3α (GSK-3α) in AML by performing 2 independent small-molecule library screens and an shRNA screen for perturbations that induced a differentiation expression signature in AML cells. GSK-3 is a serine-threonine kinase involved in diverse cellular processes, including differentiation, signal transduction, cell cycle regulation, and proliferation. We demonstrated that specific loss of GSK-3α induced differentiation in AML by multiple measurements, including induction of gene expression signatures, morphological changes, and cell surface markers consistent with myeloid maturation. GSK-3α-specific suppression also led to impaired growth and proliferation in vitro, induction of apoptosis, loss of colony formation in methylcellulose, and anti-AML activity in vivo. Although the role of GSK-3β has been well studied in cancer development, these studies support a role for GSK-3α in AML."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci46465"xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Tolliday N."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Ross L."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Li L.S."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Kung A.L."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Hahn W.C."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Aster J.C."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Chow K.T."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Galinsky I."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Stone R.M."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "DeAngelo D.J."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Ross K.N."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Roti G."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Schinzel A.C."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Alexe G."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Stegmaier K."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Hahn C.K."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Kakoza R.M."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Banerji V."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Frumm S.M."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/author | "Inguilizian H."xsd:string |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22326953 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |