| http://purl.uniprot.org/citations/22327073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22327073 | http://www.w3.org/2000/01/rdf-schema#comment | "Jun activation domain-binding protein 1 (JAB1) regulates ubiquitin-dependent protein degradation by deneddylation of cullin-based ubiquitin ligases and, therefore, plays a central role in regulating proliferation and apoptosis. Because these processes are decisive for B cell development, we investigated JAB1 functions in B cells by establishing a mouse strain with a B cell-specific JAB1 deletion. We show that JAB1 is essential for early B cell development, because the ablation of JAB1 expression blocks B cell development between the pro-B and pre-B cell stages. Furthermore, JAB1 deletion leads to aberrant expression of the apoptosis-triggering protein Fas ligand in pro-B cells. Concomitant B cell-specific overexpression of the antiapoptotic protein Bcl2 partially reverses the block in B cell development; rescued JAB1-deficient B cells reach the periphery and produce protective class-switched Abs after Borrelia burgdorferi infection. Interestingly, B cell-rescued mice exhibit no germinal centers but a striking extrafollicular plasma cell accumulation. In addition, JAB1 is essential for Bcl6 expression, a transcriptional repressor required for germinal center formation. These findings identify JAB1 as an important factor in checkpoint control during early B cell development, as well as in fate decisions in mature Ag-primed B cells."xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1101455"xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/author | "Glasner J."xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/author | "Gessner A."xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/author | "Pardi R."xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/author | "Jellusova J."xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/author | "Panattoni M."xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/author | "Weisel F."xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/author | "Sitte S."xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/pages | "2677-2686"xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/title | "JAB1 is essential for B cell development and germinal center formation and inversely regulates Fas ligand and Bcl6 expression."xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/22327073 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22327073 |
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