| http://purl.uniprot.org/citations/22327338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22327338 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular Endothelial Growth Factor-A (VEGF-A) is a key molecule in normal and tumor angiogenesis. This study addresses the role of c-ABL as a novel downstream target of VEGF-A in primary Human Umbilical Vein Endothelial Cells (HUVEC). On the basis of immunoprecipitation experiments, in vitro kinase assay and RNA interference, we demonstrate that VEGF-A induces the c-ABL kinase activity through the VEGF Receptor-2/Phosphatidylinositol-3-Kinase pathway. By treating HUVEC with the specific tyrosine kinase inhibitor STI571 and over-expressing a dominant negative c-ABL mutant, we show that the VEGF-A-activated c-ABL reduces the amplitude of Mitogen-Activated Protein Kinases (ERK1/2, JNKs and p38) activation in a dose-dependent manner by a negative feedback mechanism. By analysis of the adaptor proteins NCK1 and GRB2 mutants we further show that the negative loop on p38 is mediated by c-ABL phosphorylation at tyrosine 105 of the adaptor protein NCK1, while the phosphorylation at tyrosine 209 of GRB2 down-modulates ERK1/2 and JNKs signaling. These findings suggest that c-ABL function is to establish a correct and tightly controlled response of endothelial cells to VEGF-A during the angiogenic process."xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10456-012-9252-6"xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/author | "Anselmi F."xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/author | "Galvagni F."xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/author | "Oliviero S."xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/author | "Salameh A."xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/author | "Orlandini M."xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/author | "Lentucci C."xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/author | "Rocchigiani M."xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/author | "De Clemente C."xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/name | "Angiogenesis"xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/pages | "187-197"xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/title | "c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1."xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/22327338 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22327338 |
| http://purl.uniprot.org/citations/22327338 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22327338 |
| http://purl.uniprot.org/uniprot/#_A0A023PX70-mappedCitation-22327338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22327338 |
| http://purl.uniprot.org/uniprot/#_A0A0U2WZU8-mappedCitation-22327338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22327338 |
| http://purl.uniprot.org/uniprot/#_A0A0U2X4C8-mappedCitation-22327338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22327338 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Y3-mappedCitation-22327338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22327338 |
| http://purl.uniprot.org/uniprot/#_A0A0H4A777-mappedCitation-22327338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22327338 |
| http://purl.uniprot.org/uniprot/#_A0A0H4A7S0-mappedCitation-22327338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22327338 |
| http://purl.uniprot.org/uniprot/#_A0A0H4A7S4-mappedCitation-22327338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22327338 |