| http://purl.uniprot.org/citations/22333918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22333918 | http://www.w3.org/2000/01/rdf-schema#comment | "Maf1 is the 'master' repressor of RNA polymerase III (Pol III) transcription in yeast, and is conserved in eukaryotes. Maf1 is a phospho-integrator, with unfavourable growth conditions leading to rapid Maf1 dephosphorylation, nuclear accumulation, binding to RNA Pol III at Pol III genes and transcriptional repression. Here, we establish the protein phosphatase 4 (PP4) complex as the main Maf1 phosphatase, and define the involved catalytic (Pph3), scaffold (Psy2) and regulatory subunits (Rrd1, Tip41), as well as uninvolved subunits (Psy4, Rrd2). Multiple approaches support a central role for PP4 in Maf1 dephosphorylation, Maf1 nuclear localization and the rapid repression of Pol III in the nucleus. PP4 action is likely direct, as a portion of PP4 co-precipitates with Maf1, and purified PP4 dephosphorylates Maf1 in vitro. Furthermore, Pph3 mediates (either largely or fully) rapid Maf1 dephosphorylation in response to diverse stresses, suggesting PP4 plays a key role in the integration of cell nutrition and stress conditions by Maf1 to enable Pol III regulation."xsd:string |
| http://purl.uniprot.org/citations/22333918 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2011.501"xsd:string |
| http://purl.uniprot.org/citations/22333918 | http://purl.uniprot.org/core/author | "Cairns B.R."xsd:string |
| http://purl.uniprot.org/citations/22333918 | http://purl.uniprot.org/core/author | "Oler A.J."xsd:string |
| http://purl.uniprot.org/citations/22333918 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22333918 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/22333918 | http://purl.uniprot.org/core/pages | "1440-1452"xsd:string |
| http://purl.uniprot.org/citations/22333918 | http://purl.uniprot.org/core/title | "PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression."xsd:string |
| http://purl.uniprot.org/citations/22333918 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/22333918 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22333918 |
| http://purl.uniprot.org/citations/22333918 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22333918 |
| http://purl.uniprot.org/uniprot/P32345#attribution-98D4DF52CB57657C339E7BE0C3A2B326 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22333918 |
| http://purl.uniprot.org/uniprot/P40164#attribution-98D4DF52CB57657C339E7BE0C3A2B326 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22333918 |
| http://purl.uniprot.org/uniprot/#_P40164-mappedCitation-22333918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22333918 |
| http://purl.uniprot.org/uniprot/#_P41910-mappedCitation-22333918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22333918 |
| http://purl.uniprot.org/uniprot/#_Q12199-mappedCitation-22333918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22333918 |
| http://purl.uniprot.org/uniprot/#_P32345-mappedCitation-22333918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22333918 |
| http://purl.uniprot.org/uniprot/Q12199 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22333918 |
| http://purl.uniprot.org/uniprot/P32345 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22333918 |
| http://purl.uniprot.org/uniprot/P40164 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22333918 |
| http://purl.uniprot.org/uniprot/P41910 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22333918 |