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http://purl.uniprot.org/citations/22336504http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22336504http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To observe the expression of PECAM-1 and E-selectin in the vulnerable plagues and their relationships to myocardial Leu125Val polymorphism of PECAM-1 and Ser128Arg polymorphism of E-selectin in autopsied samples of patients with acute coronary syndrome (ACS).

Methods

We detected the expressions of PECAM-1 and E-selectin in the vulnerable plaques by immunohistochemistry on 50 autopsy samples of patients with ACS, 30 autopsy samples from non-cardiac disease patients served as control. Genetic Leu125Val polymorphism of PECAM-1 was detected by PCR-SSCP in myocardial paraffin blocks of 37 ACS cases and 43 control cases, and Ser128Arg polymorphism of E-selectin was detected by PCR-RFLP in myocardial paraffin blocks of 39 ACS cases and 43 control cases, respectively.

Results

Immunohistochemical features: (1) the incidence of positive expression in the intima of coronary artery of PECAM-1 [76.0% (38/50) vs. 26.7% (8/30)] and E-selectin [26.0% (13/50) vs. 0] was significantly higher in ACS group than in control group (all P < 0.01). (2) Expressions of PECAM-1 [58.0% (29/50) vs. 28.0% (14/50)] and E-selectin [22.0% (11/50) vs.12.0% (6/50)] were significantly higher at neovascular endothelial cells in plaques than expressions at coronary arterial endothelial cells in ACS group (all P < 0.01). (3) In 41 plaques with inflammatory infiltration, the expression rates of PECAM-1 and E-selectin in inflammatory cell density of < 10, 10 - 30 and > 30/HPF were 33.3%, 68.2%, 92.3% and 16.7%, 31.8% and 23.1%, respectively. Genotype detection results: There is significant difference in frequencies of allele in Leu125Val polymorphism (P < 0.05), but the genotype distributional frequencies were similar (P > 0.05) between ACS group and control group. There are significant differences in frequencies of allele and genotype in Ser128Arg of E-selectin polymorphism between ACS group and control group (all P < 0.05).

Conclusions

The immunohistochemical expressions of PECAM-1 and E-selectin were significantly increased at intima in vulnerable plaques of ACS group, especially in neovascular endothelial cells, and positively correlated with inflammatory cell density, suggesting that PECAM-1 and E-selectin might play an important role in inflammatory reaction and development of vulnerable plaque. E-selectin Ser128Arg polymorphism is associated with ACS, and it might be a risk factor for ACS."xsd:string
http://purl.uniprot.org/citations/22336504http://purl.uniprot.org/core/author"Fang F."xsd:string
http://purl.uniprot.org/citations/22336504http://purl.uniprot.org/core/author"Zhang W."xsd:string
http://purl.uniprot.org/citations/22336504http://purl.uniprot.org/core/author"Wang Z."xsd:string
http://purl.uniprot.org/citations/22336504http://purl.uniprot.org/core/author"Yang L."xsd:string
http://purl.uniprot.org/citations/22336504http://purl.uniprot.org/core/author"Liu D.G."xsd:string
http://purl.uniprot.org/citations/22336504http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/22336504http://purl.uniprot.org/core/name"Zhonghua Xin Xue Guan Bing Za Zhi"xsd:string
http://purl.uniprot.org/citations/22336504http://purl.uniprot.org/core/pages"1110-1116"xsd:string
http://purl.uniprot.org/citations/22336504http://purl.uniprot.org/core/title"[PECAM-1 and E-selectin expression in vulnerable plague and their relationships to myocardial Leu125Val polymorphism of PECAM-1 and Ser128Arg polymorphism of E-selectin in patients with acute coronary syndrome]."xsd:string
http://purl.uniprot.org/citations/22336504http://purl.uniprot.org/core/volume"39"xsd:string
http://purl.uniprot.org/citations/22336504http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22336504
http://purl.uniprot.org/citations/22336504http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22336504
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http://purl.uniprot.org/uniprot/#_B7Z8Y6-mappedCitation-22336504http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22336504
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http://purl.uniprot.org/uniprot/#_Q6ULR7-mappedCitation-22336504http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22336504
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http://purl.uniprot.org/uniprot/P16581http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22336504
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