| http://purl.uniprot.org/citations/22337873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22337873 | http://www.w3.org/2000/01/rdf-schema#comment | "Phagosomes are critical compartments for innate immunity. However, their role in the protection against murine listeriosis has not been examined. We describe here that listericidal phago-receptosomes are induced by the function of IFN-γ or IL-6 as centralized compartments for innate and adaptive immunity because they are able to confer protection against murine listeriosis. These phago-receptosomes elicited LLO(91-99)/CD8(+)- and LLO(189-201)/CD4(+)-specific immune responses and recruited mature dendritic cells to the vaccination sites controlled by T cells. Moreover, they present exceptional features as efficient vaccine vectors. First, they compartmentalize a novel listericidal STAT-1-mediated signaling pathway that confines multiple innate immune components to the same environment. Second, they show features of MHC class II antigen-loading competent compartments for cathepsin-D-mediated LLO processing. Third, murine cathepsin-D deficiencies fail to develop protective immunity after vaccination with listericidal phago-receptosomes induced by IFN-γ or IL-6. Therefore, it appears that the connection of STAT-1 and cathepsin-D in a single compartment is relevant for protection against listeriosis."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.348615"xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/author | "Tobes R."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/author | "Carrasco-Marin E."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/author | "Pareja E."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/author | "Holscher C."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/author | "Alvarez-Dominguez C."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/author | "Madrazo-Toca F."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/author | "Rodriguez-Del Rio E."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/author | "Frande-Cabanes E."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/author | "Lecea-Cuello M.J."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/author | "Ruiz-Saez M."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/pages | "14310-14324"xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/title | "Phagosomes induced by cytokines function as anti-Listeria vaccines: novel role for functional compartmentalization of STAT-1 protein and cathepsin-D."xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22337873 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22337873 |
| http://purl.uniprot.org/citations/22337873 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22337873 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-22337873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22337873 |
| http://purl.uniprot.org/uniprot/#_P42225-mappedCitation-22337873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22337873 |
| http://purl.uniprot.org/uniprot/#_Q3V3D6-mappedCitation-22337873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22337873 |
| http://purl.uniprot.org/uniprot/#_Q3TWR6-mappedCitation-22337873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22337873 |
| http://purl.uniprot.org/uniprot/#_Q3TXL5-mappedCitation-22337873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22337873 |