| http://purl.uniprot.org/citations/22340593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22340593 | http://www.w3.org/2000/01/rdf-schema#comment | "Elevated Aurora kinase-A expression is correlated with abrogation of DNA damage-induced apoptotic response and mitotic spindle assembly checkpoint (SAC) override in human tumor cells. We report that Aurora-A phosphorylation of p73 at serine235 abrogates its transactivation function and causes cytoplasmic sequestration in a complex with the chaperon protein mortalin. Aurora-A phosphorylated p73 also facilitates inactivation of SAC through dissociation of the MAD2-CDC20 complex in cells undergoing mitosis. Cells expressing phosphor-mimetic mutant (S235D) of p73 manifest altered growth properties, resistance to cisplatin-induced apoptosis, as well as premature dissociation of the MAD2-CDC20 complex, and accelerated mitotic exit with SAC override in the presence of spindle damage. Elevated cytoplasmic p73 in Aurora-A overexpressing primary human tumors corroborates the experimental findings."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2011.12.025"xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Mobley J.A."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Kawai H."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Sen S."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Wang H.'"xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Suzuki F."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Adams H.P."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Katayama H."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Arlinghaus R.B."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Sasai K."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Grizzle W.E."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Chakraborty S.N."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/author | "Treekitkarnmongkol W."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/pages | "196-211"xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/title | "Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73."xsd:string |
| http://purl.uniprot.org/citations/22340593 | http://purl.uniprot.org/core/volume | "21"xsd:string |