http://purl.uniprot.org/citations/22341695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22341695 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundIncreased myocyte apoptosis in diabetic hearts has been previously reported. The purpose of this study was to evaluate the effects of exercise training on cardiac survival pathways in streptozotocin (STZ)-induced diabetic rats.MethodsForty-eight male Wistar rats were randomly divided into control group (Control), STZ-induced (65 mg/kg, i.p.) diabetes (DM), and DM rats with moderate aerobic exercise training (DM-EX) on a treadmill 60 min/day, 5 days/week, for 10 weeks. Histopathological analysis, positive TUNEL assays and Western blotting were performed on the excised cardiac left ventricles from all three groups.ResultsThe components of cardiac survival pathway (insulin-like growth factor I (IGFI), IGFI-receptor (IGFI-R), phosphatidylinositol 3'-kinase (PI3K), and Akt) and the pro-survival Bcl-2 family proteins (Bcl-2, Bcl-xL, and p-BAD) were all significantly decreased in the DM group compared with the Control group whereas they were increased in the DM-EX group. In addition, the abnormal myocardial architecture, enlarged interstitial space and increased cardiac TUNEL-positive apoptotic cells were observed in the DM group, but they were reduced in the DM-EX group. The apoptotic key component, caspase-3, was significantly increased in the DM group relative to the Control group whereas it was decreased in the DM-EX group.ConclusionsExercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways, which provides one of the new beneficial effects for exercise training in diabetes."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ijcard.2012.01.031"xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Huang C.Y."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Kao C.L."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Lee S.D."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Kuo C.H."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Cheng S.M."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Ho T.J."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Ou H.C."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Yang A.L."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Lin J.A."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Chen I.J."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/author | "Wu F.N."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/name | "Int J Cardiol"xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/pages | "478-485"xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/title | "Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats."xsd:string |
http://purl.uniprot.org/citations/22341695 | http://purl.uniprot.org/core/volume | "167"xsd:string |
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