| http://purl.uniprot.org/citations/22342560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22342560 | http://www.w3.org/2000/01/rdf-schema#comment | "Although supranutrition of selenium (Se) is considered a promising anti-cancer strategy, recent human studies have shown an intriguing association between high body Se status and diabetic risk. This study was done to determine if a prolonged high intake of dietary Se actually induced gestational diabetes in rat dams and insulin resistance in their offspring. Forty-five 67-day-old female Wistar rats (n=15/diet) were fed a Se-deficient (0.01 mg/kg) corn-soy basal diet (BD) or BD+Se (as Se-yeast) at 0.3 or 3.0mg/kg from 5 weeks before breeding to day 14 postpartum. Offspring (n=8/diet) of the 0.3 and 3.0mg Se/kg dams were fed with the same respective diet until age 112 days. Compared with the 0.3mg Se/kg diet, the 3.0mg/kg diet induced hyperinsulinemia (P<0.01), insulin resistance (P<0.01), and glucose intolerance (P<0.01) in the dams at late gestation and/or day 14 postpartum and in the offspring at age 112 days. These impairments concurred with decreased (P<0.05) mRNA and/or protein levels of six insulin signal proteins in liver and muscle of dams and/or pups. Dietary Se produced dose-dependent increases in Gpx1 mRNA or GPX1 activity in pancreas, liver, and erythrocytes of dams. The 3.0mg Se/kg diet decreased Selh (P<0.01), Sepp1 (P=0.06), and Sepw1 (P<0.01), but increased Sels (P<0.05) mRNA levels in the liver of the offspring, compared with the 0.3mg Se/kg diet. In conclusion, supranutrition of Se as a Se-enriched yeast in rats induced gestational diabetes and insulin resistance. Expression of six selenoprotein genes, in particular Gpx1, was linked to this metabolic disorder."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.freeradbiomed.2012.01.017"xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Zeng M.S."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Sun L.H."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Tang J.Y."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Xia X.J."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Lei X.G."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Huang J.Q."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Zhou J.C."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/author | "Wang K.N."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/name | "Free Radic Biol Med"xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/pages | "1335-1342"xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/title | "A high-selenium diet induces insulin resistance in gestating rats and their offspring."xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/22342560 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22342560 |
| http://purl.uniprot.org/citations/22342560 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22342560 |
| http://purl.uniprot.org/uniprot/#_Q6PDW8-mappedCitation-22342560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22342560 |
| http://purl.uniprot.org/uniprot/#_M0RAM5-mappedCitation-22342560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22342560 |
| http://purl.uniprot.org/uniprot/#_P04041-mappedCitation-22342560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22342560 |